Lowry P J, Estivariz F E, Gillies G E, Kruseman A C, Linton E A
Acta Endocrinol Suppl (Copenh). 1986;276:56-62. doi: 10.1530/acta.0.111s0056.
CRF-41 and vasopressin are the major part of the hypothalamic complex responsible for the release of ACTH. The potentiated response of the corticotroph to mixtures of the peptides and their co-localization in the same neurosecretory vesicles would indicate their obligatory co-secretion in many stress situations. The occurrence of CRF at peripheral sites especially in the placenta and in the plasma of women in their third trimester of pregnancy is suggestive of further roles for this peptide although care should be exercised in interpreting simple immunohistochemical staining in certain tissues. When ACTH is released from the pituitary several other peptides which form part of its precursor are co-released. The effect of these peptides on the adrenal gland and the way their activity is expressed has led to a post-secretional proteolytic control mechanism being proposed.
促肾上腺皮质激素释放因子-41（CRF-41）和血管加压素是下丘脑复合体中负责促肾上腺皮质激素（ACTH）释放的主要部分。促肾上腺皮质激素细胞对这些肽混合物的增强反应以及它们在同一神经分泌小泡中的共定位表明，在许多应激情况下它们会共同分泌。CRF在外周部位尤其是胎盘以及妊娠晚期女性血浆中的出现，提示了该肽的其他作用，不过在解释某些组织中的简单免疫组化染色时应谨慎。当ACTH从垂体释放时，其前体的其他几种肽也会共同释放。这些肽对肾上腺的作用及其活性表达方式促使人们提出了一种分泌后蛋白水解控制机制。
