Rommerts F F, Themmen A P
Acta Endocrinol Suppl (Copenh). 1986;276:76-84. doi: 10.1530/acta.0.111s0076.
Studies which have contributed to the present knowledge about peripheral effects of LHRH agonists are reviewed and compared with studies on the mechanism of effects of LHRH on the pituitary gland. It is concluded that LHRH or LHRH agonists can directly stimulate or inhibit the activity of gonadal cells from rats but not from man. Effects of LHRH on other human or rat peripheral tissues have been observed. LHRH- or LHRH-like molecules can be isolated from rat testes, but there is not enough evidence to consider LHRH- or LHRH-like peptides as general and important paracrine factors for regulation of gonadal function. On the other hand studies with LHRH agonists have stimulated investigations on cell-cell interactions in the gonads and data have been collected which show that peptides which are less or non-related to LHRH can modulate functional properties of gonadal cells via pathways not employed by gonadotropins.
本文综述了有助于我们目前了解促性腺激素释放激素（LHRH）激动剂外周效应的研究，并将其与关于LHRH对垂体作用机制的研究进行了比较。得出的结论是，LHRH或LHRH激动剂可直接刺激或抑制大鼠而非人类性腺细胞的活性。已观察到LHRH对其他人类或大鼠外周组织的作用。可从大鼠睾丸中分离出LHRH或LHRH样分子，但尚无足够证据将LHRH或LHRH样肽视为调节性腺功能的普遍且重要的旁分泌因子。另一方面，使用LHRH激动剂的研究推动了对性腺中细胞间相互作用的研究，并收集到的数据表明，与LHRH相关性较低或无关的肽可通过促性腺激素未采用的途径调节性腺细胞的功能特性。
