Wang Rui, Wei Yamin, Teng Junfang
Rui Wang Neurological Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450000, China.
Yamin Wei Neurological Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450000, China.
Pak J Med Sci. 2018 Jul-Aug;34(4):855-858. doi: 10.12669/pjms.344.14513.
To investigate the effects of levels of D-dimer and N-terminal pro-brain natriuretic peptide (NT-pro BNP) on the prognosis of patients with acute cerebral infarction.
One hundred and twenty-four patients with acute cerebral infarction who were admitted to the hospital between July 2014 and July 2016 were selected as the observation group; 100 normal people who had health examination in the center of physical examination of our hospital were selected as the control group. The levels of D-dimer and NT-pro BNP of the two groups were observed; the correlation between the levels of plasma NT-pro BNP and D-dimer and area of cerebral infarction, complications and death condition of the observation group was investigated.
The levels of D-dimer and NT-pro BNP of the observation group were much higher than those of the control group, and the difference was statistically significant (P<0.05). The levels of D-dimer and NT-pro BNP of the observation group were significantly higher than those of the control group, and the difference had statistical significance (P<0.05). The levels of plasma NT-pro BNP and D-dimer of the patients with disturbance of consciousness and high blood pressure were apparently higher than those with no disturbance of consciousness and normal blood pressure, and there was a statistically significant difference (P<0.05). The patients were followed up for half a year. The levels of D-dimer and NT-pro BNP of the dead patients were much higher than those of the survived patients on admission.
The levels of plasma NT-pro BNP and D-dimer can reflect the disease condition and prognosis of patients with acute cerebral infarction. Higher levels of NT-pro BNP and D-dimer indicates poorer prognosis. This work can provide a guidance for the clinical treatment of acute cerebral infarction.
探讨D - 二聚体和N末端脑钠肽前体（NT - pro BNP）水平对急性脑梗死患者预后的影响。
选取2014年7月至2016年7月入院的124例急性脑梗死患者作为观察组；选取在我院体检中心进行健康体检的100名正常人为对照组。观察两组患者的D - 二聚体和NT - pro BNP水平；研究观察组患者血浆NT - pro BNP和D - 二聚体水平与脑梗死面积、并发症及死亡情况之间的相关性。
观察组患者的D - 二聚体和NT - pro BNP水平明显高于对照组，差异具有统计学意义（P<0.05）。观察组患者的D - 二聚体和NT - pro BNP水平显著高于对照组，差异有统计学意义（P<0.05）。意识障碍和高血压患者的血浆NT - pro BNP和D - 二聚体水平明显高于无意识障碍和血压正常的患者，差异有统计学意义（P<0.05）。对患者进行半年随访。死亡患者入院时的D - 二聚体和NT - pro BNP水平明显高于存活患者。
血浆NT - pro BNP和D - 二聚体水平可反映急性脑梗死患者的病情及预后。NT - pro BNP和D - 二聚体水平越高，预后越差。本研究可为急性脑梗死的临床治疗提供指导。
