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Parkinsonism Relat Disord. 2016 Jun;27:47-53. doi: 10.1016/j.parkreldis.2016.04.009. Epub 2016 Apr 11.
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Severity of mild cognitive impairment in early Parkinson's disease contributes to poorer quality of life.早期帕金森病轻度认知障碍的严重程度导致生活质量较差。
Parkinsonism Relat Disord. 2014 Oct;20(10):1071-5. doi: 10.1016/j.parkreldis.2014.07.004. Epub 2014 Jul 18.
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Clinical spectrum of Parkinson's disease from Pakistan.巴基斯坦帕金森病的临床谱
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Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030.2005年至2030年人口最多国家的帕金森病患者预计人数。
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Effect of levodopa on cognitive function in Parkinson's disease with and without dementia and dementia with Lewy bodies.左旋多巴对伴或不伴痴呆的帕金森病及路易体痴呆认知功能的影响。
J Neurol Neurosurg Psychiatry. 2006 Dec;77(12):1323-8. doi: 10.1136/jnnp.2006.098079. Epub 2006 Sep 4.
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In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease.使用[11C](R)-PK11195正电子发射断层显像术对特发性帕金森病中小胶质细胞激活进行体内成像。
Neurobiol Dis. 2006 Feb;21(2):404-12. doi: 10.1016/j.nbd.2005.08.002. Epub 2005 Sep 21.
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A comparison of degeneration in motor thalamus and cortex between progressive supranuclear palsy and Parkinson's disease.进行性核上性麻痹与帕金森病中运动丘脑和皮质退变的比较。
Brain. 2005 Oct;128(Pt 10):2272-80. doi: 10.1093/brain/awh596. Epub 2005 Jul 13.
8
Dopaminergic modulation of cognitive function-implications for L-DOPA treatment in Parkinson's disease.多巴胺能对认知功能的调节——对帕金森病左旋多巴治疗的启示
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The Rowland Universal Dementia Assessment Scale (RUDAS): a multicultural cognitive assessment scale.罗兰通用痴呆评估量表（RUDAS）：一种多元文化认知评估量表。
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10
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左旋多巴对特发性帕金森病皮质功能障碍、健康相关生活质量及疲劳严重程度的反应

L-Dopa response to Cortical Dysfunctions, health related quality of life and Fatigue Severity in Idiopathic Parkinson's disease.

作者信息

Gul Amara, Yousaf Javed

机构信息

Dr. Amara Gul, PhD. Department of Applied Psychology, The Islamia University of Bahawalpur, Bahawalpur. Pakistan.

Javed Yousaf, M.Phil. Department of Applied Psychology, The Islamia University of Bahawalpur, Bahawalpur. Pakistan.

出版信息

Pak J Med Sci. 2018 Jul-Aug;34(4):1014-1018. doi: 10.12669/pjms.344.14753.

DOI:10.12669/pjms.344.14753
PMID:30190772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6115581/
Abstract

OBJECTIVES

To determine (i) levodopa (L-Dopa) responsiveness on cortical functions, health related quality of life and fatigue severity (ii) relationship between cortical functions, health related quality of life and fatigue severity post L-Dopa treatment of patients with idiopathic Parkinson's Disease (I-PD).

METHODS

Participants included 50 patients diagnosed with I-PD who were attending Civil and Bahawal Victoria Hospital, Bahawalpur, Pakistan during May 2016 to July 2017 and 50 healthy individuals (HI) took part in the study. Participants completed Cortical Function Assessment, Parkinson's Disease Questionnaire and Fatigue Severity Scale. Patients were tested twice on these measures: pre and post- L-Dopa treatment.

RESULTS

Patients with I-PD showed cortical functioning deficits, deteriorated health related quality of life and experience of severe fatigue, in contrast with HI. There was significant improvement in cortical functioning and quality of life while reduction in fatigue severity was observed after three months of L-Dopa medication in I- PD patients. Higher cortical functioning deficits correlated with deteriorated health related quality of life and severe fatigue. Cortical functioning was a significant predictor of health related quality of life and fatigue severity.

CONCLUSION

L-Dopa is an effective treatment for cortical dysfunctions, health related quality of life and fatigue in I-PD. Cortical functioning is a significant marker of quality of life and fatigue in patients with I-PD.

摘要

目的

确定（i）左旋多巴（L-多巴）对皮质功能、健康相关生活质量和疲劳严重程度的反应（ii）特发性帕金森病（I-PD）患者接受L-多巴治疗后皮质功能、健康相关生活质量和疲劳严重程度之间的关系。

方法

参与者包括2016年5月至2017年7月期间在巴基斯坦巴哈瓦尔布尔的公民和巴哈瓦尔维多利亚医院就诊的50例被诊断为I-PD的患者，以及50名健康个体（HI）参与了该研究。参与者完成了皮质功能评估、帕金森病问卷和疲劳严重程度量表。患者在这些测量指标上进行了两次测试：L-多巴治疗前和治疗后。

结果

与HI相比，I-PD患者表现出皮质功能缺陷、健康相关生活质量下降和严重疲劳体验。I-PD患者在接受L-多巴治疗三个月后，皮质功能和生活质量有显著改善，同时疲劳严重程度降低。较高的皮质功能缺陷与健康相关生活质量下降和严重疲劳相关。皮质功能是健康相关生活质量和疲劳严重程度的重要预测指标。

结论

L-多巴是治疗I-PD患者皮质功能障碍、健康相关生活质量和疲劳的有效药物。皮质功能是I-PD患者生活质量和疲劳的重要标志。