Gazzé Gabriel
Melanoma Manag. 2015 Feb;2(1):75-82. doi: 10.2217/mmt.14.33. Epub 2015 Feb 25.
Metastatic melanoma is a disease with a historically dismal survival of 6-9 months with treatment. It is considered an incurable disease and resistant to conventional chemotherapy. We have learned much about the role of newer targets in the development of melanoma which has helped us in developing targeted therapy and improving immunotherapy for the treatment of melanoma. These new therapies have a different adverse event profile from conventional chemotherapy. We will define these and their management from the perspective of the oncology pharmacist. We will also discuss the role that the oncology pharmacist can play in optimizing therapy and side effect management in the multidisciplinary team treating patients that have unresectable or metastatic melanoma.
转移性黑色素瘤是一种历史上经治疗后生存期仅6至9个月、预后极差的疾病。它被认为是一种无法治愈的疾病,对传统化疗具有耐药性。我们已经对黑色素瘤发展过程中新型靶点的作用有了很多了解,这有助于我们开发靶向治疗并改进黑色素瘤的免疫治疗。这些新疗法的不良事件特征与传统化疗不同。我们将从肿瘤药师的角度对这些不良事件及其管理进行定义。我们还将讨论肿瘤药师在多学科团队治疗不可切除或转移性黑色素瘤患者时,在优化治疗和副作用管理方面所能发挥的作用。