血清蛋白DKK1水平高预示着肝癌患者肝切除术后预后不良。
High level of serum protein DKK1 predicts poor prognosis for patients with hepatocellular carcinoma after hepatectomy.
作者信息
Shen Qiujin, Yang Xin-Rong, Tan Yexiong, You Haiyan, Xu Yang, Chu Wei, Ge Tianxiang, Zhou Jian, Qiu Shuang-Jian, Shi Ying-Hong, Zhang Zhigang, Gu Jianren, Wang Hongyang, Fan Jia, Qin Wenxin
机构信息
State Key Laboratory of Oncogenes & Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, No.25/Ln 2200 XieTu Road, Shanghai 200032, China.
Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis & Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China.
出版信息
Hepat Oncol. 2015 Jul;2(3):231-244. doi: 10.2217/hep.15.12. Epub 2015 Apr 1.
AIM
To evaluate prognostic significance of DKK1 for hepatocelluar carcinoma.
MATERIALS & METHODS: We enrolled a test cohort consisting of 266 hepatitis virus B-related hepatocelluar carcinoma patients who had undergone hepatectomy and a validation cohort of 95. Associations of DKK1 with overall survival and time to recurrence were determined by Cox proportional hazards regression model.
RESULTS
High levels of preoperative serum DKK1 were associated with poor overall survival and higher recurrence rate and DKK1 was an independent prognostic predictor. Moreover, DKK1 maintained ability to predict recurrence for patients with low recurrence risk. Double positives of DKK1 and AFP indicated the worst overall survival and the highest recurrence rate compared with either used alone. Patients with preoperatively and 1-day postoperatively positive DKK1 had higher recurrence rates than those whose values were both negative. Similar results were found in the validation cohort.
CONCLUSION
Serum DKK1 could predict prognosis of hepatocelluar carcinoma after hepatectomy.
目的
评估DKK1对肝细胞癌的预后意义。
材料与方法
我们纳入了一个由266例接受肝切除术的乙型肝炎病毒相关肝细胞癌患者组成的测试队列和一个95例的验证队列。通过Cox比例风险回归模型确定DKK1与总生存期和复发时间的关联。
结果
术前血清DKK1水平高与总生存期差和复发率高相关，且DKK1是一个独立的预后预测指标。此外，DKK1对低复发风险患者仍有预测复发的能力。与单独使用DKK1或AFP相比，DKK1和AFP双阳性患者的总生存期最差，复发率最高。术前和术后1天DKK1均为阳性的患者复发率高于两者均为阴性的患者。在验证队列中也发现了类似结果。
结论
血清DKK1可预测肝切除术后肝细胞癌的预后。
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