• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Dickkopf-1在癌症患者中的预后作用。

Prognostic role of dickkopf-1 in patients with cancer.

作者信息

Huang Junfang, Lu Tao, Kuang Wenbing

机构信息

Department of general medicine of Shenzhen Longhua District Central Hospital.

Clinical Laboratory Center of Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University School of Medcine, Shaoxing, China.

出版信息

Medicine (Baltimore). 2020 May 22;99(21):e20388. doi: 10.1097/MD.0000000000020388.

DOI:10.1097/MD.0000000000020388
PMID:32481337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7250037/
Abstract

As an antagonist for the WNT signal passway, dickkopf-1(DKK1) have a great important role in the occurence and development of various type cancer. The present paper performed a meta-analysis to evaluate the predictive significance of DKK1 in cancer.To assess the relationship between the expression of DKK1 and prognostic role in human cancers, a total of 16 articals were screened from the multiple online databases (Pubmed, EMBASE, CNKI, Web of Science and Google Scholar) in our study. By using the STATA soft,pooled hazard ratio and 95% confidence intervals of overall survival (OS), progression-free survival, disease-free survival and time to recurrence were used to evaluate the strength of this relationship.The meta-analysis showed that higher expression of DKK1 was significantly associated with shorter OS in cancer patients. In stratified analyzes, the higher expression of DKK1 could reduced the OS in patients with breast cancer,digestive system cancer and urogenital system cancer, but not patients with the lung cancer. It also showed that higher expression of DKK1 was significantly associated with shorter progression-free survival, disease-free survival and time to recurrence in cancer patients.The present study indicate that higher expression of DKK1 predict an unfavorable clinical outcome in patients with breast cancer, digestive system cancer and urogenital system cancer.

摘要

作为WNT信号通路的拮抗剂， Dickkopf-1（DKK1）在各类癌症的发生发展中具有极其重要的作用。本文进行了一项荟萃分析，以评估DKK1在癌症中的预测意义。为了评估DKK1表达与人类癌症预后作用之间的关系，在我们的研究中，从多个在线数据库（PubMed、EMBASE、CNKI、Web of Science和谷歌学术）中共筛选出16篇文章。通过使用STATA软件，采用合并风险比和总生存期（OS）、无进展生存期、无病生存期及复发时间的95%置信区间来评估这种关系的强度。荟萃分析表明，DKK1高表达与癌症患者较短的OS显著相关。在分层分析中，DKK1高表达可降低乳腺癌、消化系统癌症和泌尿生殖系统癌症患者的OS，但对肺癌患者无此影响。研究还表明，DKK1高表达与癌症患者较短的无进展生存期、无病生存期及复发时间显著相关。本研究表明，DKK1高表达预示着乳腺癌、消化系统癌症和泌尿生殖系统癌症患者的临床结局不佳。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3604/7250037/66b88dbcda0b/medi-99-e20388-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3604/7250037/c60cf12ef48a/medi-99-e20388-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3604/7250037/eb6eb00fb4d5/medi-99-e20388-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3604/7250037/d1a154421a0c/medi-99-e20388-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3604/7250037/efd7ddcccce8/medi-99-e20388-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3604/7250037/66b88dbcda0b/medi-99-e20388-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3604/7250037/c60cf12ef48a/medi-99-e20388-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3604/7250037/eb6eb00fb4d5/medi-99-e20388-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3604/7250037/d1a154421a0c/medi-99-e20388-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3604/7250037/efd7ddcccce8/medi-99-e20388-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3604/7250037/66b88dbcda0b/medi-99-e20388-g006.jpg

相似文献

1
Prognostic role of dickkopf-1 in patients with cancer.Dickkopf-1在癌症患者中的预后作用。
Medicine (Baltimore). 2020 May 22;99(21):e20388. doi: 10.1097/MD.0000000000020388.
2
Prognostic value of Dickkopf-1 and ß-catenin expression in advanced gastric cancer.晚期胃癌中 Dickkopf-1 和 β-连环蛋白表达的预后价值。
BMC Cancer. 2018 May 2;18(1):506. doi: 10.1186/s12885-018-4420-8.
3
Prognostic value of Dickkopf-1 and ß-catenin expression according to the antitumor immunity of CD8-positive tumor-infiltrating lymphocytes in biliary tract cancer.根据胆管癌中 CD8 阳性肿瘤浸润淋巴细胞的抗肿瘤免疫，Dickkopf-1 和 ß-连环蛋白表达的预后价值。
Sci Rep. 2022 Feb 4;12(1):1931. doi: 10.1038/s41598-022-05914-4.
4
Prognostic significance of dickkopf-1 overexpression in solid tumors: a meta-analysis.Dickkopf-1蛋白过表达在实体瘤中的预后意义：一项荟萃分析。
Tumour Biol. 2014 Apr;35(4):3145-54. doi: 10.1007/s13277-013-1411-x. Epub 2013 Nov 21.
5
Clinical significance of serum and tissue Dickkopf-1 levels in patients with gastric cancer.胃癌患者血清和组织 Dickkopf-1 水平的临床意义。
Clin Chim Acta. 2012 Nov 12;413(21-22):1753-60. doi: 10.1016/j.cca.2012.07.003. Epub 2012 Jul 13.
6
Expression of Cancer Stem Cell-associated mRNA Serves as Prognostic Marker for Hepatocellular Carcinoma.癌症干细胞相关mRNA的表达作为肝细胞癌的预后标志物
Anticancer Res. 2017 Sep;37(9):4881-4888. doi: 10.21873/anticanres.11897.
7
Prognostic Significance of Dickkopf-1 in Gastric Cancer Survival: A Meta-Analysis.Dickkopf-1在胃癌生存中的预后意义：一项荟萃分析
Genet Test Mol Biomarkers. 2016 Apr;20(4):170-5. doi: 10.1089/gtmb.2015.0154. Epub 2016 Mar 29.
8
Serum dickkopf-1 is a novel serological biomarker for the diagnosis and prognosis of pancreatic cancer.血清Dickkopf-1是一种用于胰腺癌诊断和预后的新型血清学生物标志物。
Oncotarget. 2015 Aug 14;6(23):19907-17. doi: 10.18632/oncotarget.4529.
9
Long-term prognostic impact of osteopontin and Dickkopf-related protein 1 in patients with hepatocellular carcinoma after hepatectomy.骨桥蛋白和Dickkopf相关蛋白1对肝癌肝切除术后患者的长期预后影响
Pathol Res Pract. 2018 Jun;214(6):814-820. doi: 10.1016/j.prp.2018.05.002. Epub 2018 May 6.
10
The Wnt pathway regulator DKK1 is preferentially expressed in hormone-resistant breast tumours and in some common cancer types.Wnt信号通路调节因子DKK1在激素抵抗性乳腺癌及某些常见癌症类型中优先表达。
Br J Cancer. 2007 Feb 26;96(4):646-53. doi: 10.1038/sj.bjc.6603579. Epub 2007 Jan 23.

引用本文的文献

1
AXL tyrosine kinase inhibitor TP-0903 induces ROS trigger neuroblastoma cell apoptosis via targeting the miR-335-3p/DKK1 expression.AXL酪氨酸激酶抑制剂TP-0903通过靶向miR-335-3p/DKK1表达诱导活性氧触发神经母细胞瘤细胞凋亡。
Cell Death Discov. 2025 Aug 13;11(1):378. doi: 10.1038/s41420-025-02681-9.
2
DKK1 as a chemoresistant protein modulates oxaliplatin responses in colorectal cancer.作为一种化疗抗性蛋白，DKK1调节结直肠癌中奥沙利铂的反应。
Oncogenesis. 2024 Sep 27;13(1):34. doi: 10.1038/s41389-024-00537-y.
3
RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis.

本文引用的文献

1
Correlations of DKK1 with incidence and prognosis of breast cancer.DKK1与乳腺癌发病率及预后的相关性。
J BUON. 2019 Jan-Feb;24(1):26-32.
2
Dickkopf-1 (DKK1) promotes tumor growth via Akt-phosphorylation and independently of Wnt-axis in Barrett's associated esophageal adenocarcinoma.迪克kopf-1（DKK1）通过Akt磷酸化促进肿瘤生长，且在巴雷特食管相关腺癌中与Wnt轴无关。
Am J Cancer Res. 2019 Feb 1;9(2):330-346. eCollection 2019.
3
Baicalin induced colon cancer cells apoptosis through miR-217/DKK1-mediated inhibition of Wnt signaling pathway.
RSPO2 和 RANKL 通过 LGR4 信号调节破骨细胞前转移龛形成和骨转移。
J Clin Invest. 2022 Jan 18;132(2). doi: 10.1172/JCI144579.
黄芩苷通过miR-217/DKK1介导的Wnt信号通路抑制诱导结肠癌细胞凋亡。
Mol Biol Rep. 2019 Apr;46(2):1693-1700. doi: 10.1007/s11033-019-04618-9. Epub 2019 Feb 8.
4
Correlations of DKK1 with pathogenesis and prognosis of human multiple myeloma.DKK1 与人多发性骨髓瘤发病机制和预后的相关性。
Cancer Biomark. 2019;24(2):195-201. doi: 10.3233/CBM-181909.
5
BPI-9016M, a c-Met inhibitor, suppresses tumor cell growth, migration and invasion of lung adenocarcinoma via miR203-DKK1.BPI-9016M，一种 c-Met 抑制剂，通过 miR203-DKK1 抑制肺腺癌肿瘤细胞的生长、迁移和侵袭。
Theranostics. 2018 Nov 12;8(21):5890-5902. doi: 10.7150/thno.27667. eCollection 2018.
6
High level of serum protein DKK1 predicts poor prognosis for patients with hepatocellular carcinoma after hepatectomy.血清蛋白DKK1水平高预示着肝癌患者肝切除术后预后不良。
Hepat Oncol. 2015 Jul;2(3):231-244. doi: 10.2217/hep.15.12. Epub 2015 Apr 1.
7
Prognostic value of Dickkopf-1 and ß-catenin expression in advanced gastric cancer.晚期胃癌中 Dickkopf-1 和 β-连环蛋白表达的预后价值。
BMC Cancer. 2018 May 2;18(1):506. doi: 10.1186/s12885-018-4420-8.
8
Recent Progress of Wnt Pathway Inhibitor Dickkopf-1 in Liver Cancer.Wnt信号通路抑制剂Dickkopf-1在肝癌中的研究进展
J Nanosci Nanotechnol. 2018 Aug 1;18(8):5192-5206. doi: 10.1166/jnn.2018.14636.
9
L-securinine inhibits the proliferation of A549 lung cancer cells and promotes DKK1 promoter methylation.L-一叶萩碱抑制A549肺癌细胞的增殖并促进DKK1启动子甲基化。
Oncol Lett. 2017 Oct;14(4):4243-4248. doi: 10.3892/ol.2017.6693. Epub 2017 Aug 1.
10
Differential effects on lung and bone metastasis of breast cancer by Wnt signalling inhibitor DKK1.Wnt 信号抑制剂 DKK1 对乳腺癌肺转移和骨转移的差异影响。
Nat Cell Biol. 2017 Oct;19(10):1274-1285. doi: 10.1038/ncb3613. Epub 2017 Sep 11.