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Regorafenib and the RESORCE trial: a new second-line option for hepatocellular carcinoma patients.瑞戈非尼与RESORCE试验:肝细胞癌患者的新二线治疗选择
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Outcomes of sequential treatment with sorafenib followed by regorafenib for HCC: Additional analyses from the phase III RESORCE trial.序贯索拉非尼后regorafenib 治疗 HCC 的结果:来自 III 期 RESORCE 试验的附加分析。
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Sorafenib is associated with a reduced rate of tumour growth and liver function deterioration in HCV-induced hepatocellular carcinoma.索拉非尼可降低 HCV 相关肝细胞癌的肿瘤生长速度和肝功能恶化速度。
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Implications of Immunotherapy in Hepatobiliary Tumors.免疫疗法在肝胆肿瘤中的应用
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瑞戈非尼与RESORCE试验:肝细胞癌患者的新二线治疗选择

Regorafenib and the RESORCE trial: a new second-line option for hepatocellular carcinoma patients.

作者信息

Bruix Jordi

机构信息

BCLC Group, Liver Unit, Hospital Clinic, University of Barcelona, IDIBAPS, CIBEREHD, Villarroel 170, Barcelona 08036, Spain.

出版信息

Hepat Oncol. 2016 Aug;3(3):187-189. doi: 10.2217/hep-2016-0007. Epub 2016 Aug 19.

DOI:10.2217/hep-2016-0007
PMID:30191039
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6095319/
Abstract

Dr Jordi Bruix is the Head of the Barcelona Clinic Liver Cancer (BCLC) group at the Hospital Clinic (University of Barcelona, Spain) and Director of the Network for Research in Liver and Digestive Disease (CIBEREHD) in the Spanish Research Institute. His research has changed the diagnosis and treatment of liver cancer. Major highlights include: development of the BCLC staging and treatment; development of diagnostic criteria for hepatocellular carcinoma; identification of the value of portal pressure in predicting prognosis after resection; and acting as principal investigator of the Phase III trials that have shown the benefits of chemoembolization, sorafenib and regorafenib for patients with liver cancer. He has authored the European Assoaciation for the Study of the Liver, American Association for the Study of Liver Diseases and World Gastroenterology Organization Practice Guidelines and the United Network for Organ Sharing hepatocellular carcinoma (HCC) diagnostic criteria.

摘要

霍尔迪·布鲁伊克斯博士是西班牙巴塞罗那大学附属医院临床医院巴塞罗那临床肝癌(BCLC)小组的负责人,也是西班牙研究所肝脏与消化系统疾病研究网络(CIBEREHD)的主任。他的研究改变了肝癌的诊断和治疗方式。主要成就包括:制定BCLC分期和治疗方案;制定肝细胞癌的诊断标准;确定门静脉压力在预测肝切除术后预后方面的价值;担任多项III期试验的主要研究者,这些试验证明了经动脉化疗栓塞、索拉非尼和瑞戈非尼对肝癌患者的疗效。他撰写了欧洲肝脏研究协会、美国肝病研究协会和世界胃肠病学组织的实践指南以及器官共享联合网络肝细胞癌(HCC)诊断标准。