Akinwande Olaguoke, Shah Veer, Mills Abigail, Noda Christopher, Weiner Eric, Foltz Gretchen, Saad Nael
Division of Interventional Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Hepat Oncol. 2017 Jul;4(3):75-81. doi: 10.2217/hep-2017-0005. Epub 2017 Oct 30.
Compare radioembolization (Y90) and chemoembolization (CE) for the treatment of unresectable intrahepatic cholangiocarcinoma (UICC).
MATERIALS & METHODS: Institutional Review Board-approved, retrospective search was performed. Forty patients with UICC were treated with either Y90 (n = 25, 39 treatments) or CE (n = 15, 35 treatments). Comparative analysis was performed using Student's and fisher-exact tests. Multivariable-logistic regression was also performed.
Median ages were 60 and 64 years for CE and Y90 groups, respectively (p = 0.798). Patient variables including age, Eastern Cooperative Oncology Group score, tumor burden, extra-hepatic disease, prior chemotherapy and prior surgery were similar between groups. Adverse events were similar in both groups (CE 20%, Y90 26%; p > 0.9). Overall response rate (CE 6%, Y90 4%; p > 0.9) and disease control rate (CE 46%, Y90 48%; p > 0.9) were statistically similar. Multilogistic regression did not identify any variables that correlated with disease control rate, including Eastern Cooperative Oncology Group score and tumor burden.
Our observation shows that CE and Y90 display similar toxicity and disease control in the treatment of UICC.
比较放射性栓塞（钇-90）和化学栓塞（CE）治疗不可切除性肝内胆管癌（UICC）的效果。
进行了经机构审查委员会批准的回顾性研究。40例UICC患者接受了钇-90治疗（n = 25，共39次治疗）或CE治疗（n = 15，共35次治疗）。采用学生t检验和Fisher精确检验进行对比分析。还进行了多变量逻辑回归分析。
CE组和钇-90组的中位年龄分别为60岁和64岁（p = 0.798）。两组患者的变量，包括年龄、东部肿瘤协作组评分、肿瘤负荷、肝外疾病、既往化疗史和既往手术史相似。两组的不良事件相似（CE组20%，钇-90组26%；p > 0.9）。总体缓解率（CE组6%，钇-90组4%；p > 0.9）和疾病控制率（CE组46%，钇-90组48%；p > 0.9）在统计学上相似。多逻辑回归未发现任何与疾病控制率相关的变量，包括东部肿瘤协作组评分和肿瘤负荷。
我们的观察表明，在治疗UICC方面，CE和钇-90显示出相似的毒性和疾病控制效果。
