Chin J H, Oon C J, Tan L, Yong Y M
Ann Acad Med Singap. 1986 Apr;15(2):162-8.
Four patients with advanced hepatocellular carcinoma, but with stage I functional disease, were treated with intrahepatic arterial lipoidal mixed with small doses of Adriamycin (20 mg) and Mitomycin C (10 mg). Regression was seen in 3 out of the 4 patients. In 2 patients, there was substantial regression of tumour clinically, radiologically and biochemically. The treatment was tolerable without marrow depression or deterioration of liver function. Mild fever (37 degrees C) was seen in 2 and epigastric pain in 1. This form of treatment opens up scope for further improvement in the management of irresectable hepatocellular carcinoma.
4例晚期肝细胞癌患者，虽处于I期功能疾病阶段，但接受了肝内动脉注射脂质体并混合小剂量阿霉素（20毫克）和丝裂霉素C（10毫克）的治疗。4例患者中有3例出现肿瘤消退。2例患者在临床、放射学和生物化学方面肿瘤有显著消退。该治疗耐受性良好，未出现骨髓抑制或肝功能恶化。2例出现低热（37摄氏度），1例出现上腹部疼痛。这种治疗方式为不可切除肝细胞癌的管理带来了进一步改善的空间。
