Xue Xian-Jun, Jiang Yan, Chen Liang, Chen Shao-Liang
Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Department of Cardiology, Affiliated Hospital of Yangzhou University, Yangzhou First People's Hospital, Yangzhou, China.
Microcirculation. 2018 Nov;25(8):e12504. doi: 10.1111/micc.12504. Epub 2018 Oct 8.
To investigate the correlation between the EG and the severity of coronary atherosclerosis.
A total of193 subjects were divided into two groups. A SDF video microscope with a glycocalyx thickness measurement system was used to visualize the sublingual microcirculation. The levels of HA in the peripheral circulation and coronary circulation were determined via enzyme-linked immunosorbent assay. The number of coronary artery lesions and the Gensini score were used to evaluate the severity of the coronary atherosclerosis.
EG thickness in the coronary heart disease (CHD) group (242.18 ± 10.10 nm) was lower than that in the NON-CHD group (251.78 ± 10.59 nm, P < 0.001). There was a negative correlation between the EG thickness and the number of coronary lesions and the Gensini score. The level of intracoronary HA in the CHD group (48.60, 126.27) was higher than that in the NON-CHD group (20.60, 34.45, P < 0.001), and it was positively correlated with the number of coronary lesions and the Gensini score.
EG damage was correlated with the occurrence and development of coronary atherosclerosis. The EG thickness in the capillaries of the oral submucosa and the intracoronary HA level can be used as auxiliary indexes to assess the severity of coronary atherosclerosis.
探讨内皮糖萼（EG）与冠状动脉粥样硬化严重程度之间的相关性。
将193名受试者分为两组。使用配有糖萼厚度测量系统的同步辐射傅里叶变换红外光谱（SDF）视频显微镜观察舌下微循环。通过酶联免疫吸附测定法测定外周循环和冠状动脉循环中透明质酸（HA）的水平。采用冠状动脉病变数量和Gensini评分评估冠状动脉粥样硬化的严重程度。
冠心病（CHD）组的EG厚度（242.18±10.10nm）低于非冠心病组（251.78±10.59nm，P<0.001）。EG厚度与冠状动脉病变数量和Gensini评分呈负相关。CHD组冠状动脉内HA水平（48.60，126.27）高于非CHD组（20.60，34.45，P<0.001），且与冠状动脉病变数量和Gensini评分呈正相关。
EG损伤与冠状动脉粥样硬化的发生发展相关。口腔黏膜下层毛细血管的EG厚度和冠状动脉内HA水平可作为评估冠状动脉粥样硬化严重程度的辅助指标。
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