丁酸钠对丁酸盐敏感和耐药肥大细胞瘤细胞中环磷酸腺苷磷酸二酯酶活性的差异作用。
Differential effect of sodium butyrate on cyclic AMP phosphodiesterase activities in butyrate sensitive and resistant mastocytoma cells.
作者信息
Mori Y, Tanigaki Y, Yamaguchi A, Akedo H
出版信息
Biochem Biophys Res Commun. 1986 Aug 14;138(3):1030-6. doi: 10.1016/s0006-291x(86)80385-0.
The effect of sodium butyrate on the intracellular cyclic AMP levels and the activities of cyclic AMP-regulating enzymes were examined in two types of mastocytoma p-815 cells in culture: one type (S cell) was sensitive and the other (R cell) was resistant to the induction of differentiation by sodium butyrate. In the presence of sodium butyrate, adenylate cyclase activity increased in both S and R cells to the same degree, whereas the level of cyclic AMP was elevated only in S cells. Cyclic AMP phosphodiesterase activity increased in R cells but not in S cells. Cyclic AMP phosphodiesterase activities of two cell populations differed in their response to sodium butyrate and they seem to have an important role in regulating cellular level of cyclic AMP that might be an important factor in controlling cell differentiation.
研究了丁酸钠对两种培养的肥大细胞瘤P - 815细胞内环磷酸腺苷（cAMP）水平及环磷酸腺苷调节酶活性的影响：一种类型（S细胞）对丁酸钠诱导的分化敏感，另一种（R细胞）则对丁酸钠诱导的分化具有抗性。在丁酸钠存在的情况下，腺苷酸环化酶活性在S细胞和R细胞中均有相同程度的增加，而环磷酸腺苷水平仅在S细胞中升高。环磷酸腺苷磷酸二酯酶活性在R细胞中增加，而在S细胞中未增加。两个细胞群体的环磷酸腺苷磷酸二酯酶活性对丁酸钠的反应不同，它们似乎在调节细胞内环磷酸腺苷水平方面具有重要作用，而这可能是控制细胞分化的一个重要因素。
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