Social Factors in Ethanol Sensitization.

Behavioral sensitization is a neuroadaptive process characterized by an increase in a particular behavior after repeated exposure to drugs or other stimuli, such as stress. Sensitization can also be extended to neurochemical and neuroendocrine sensitization. Several factors can influence sensitization to the effects of ethanol. For instance, stress is an important component in addiction that can strengthen ethanol-induced behaviors. In animal models, stressful situations can be induced by alterations in social aspects of the animal's environment, such as maternal separation, social conflicts, and housing conditions. Social conflict models involve acute, chronic or intermittent interaction of an animal to a conspecific and can occur at any stage of life, including preweaning, adolescence or adulthood. These events can influence ethanol-induced behavioral sensitization in different ways, such as increases in locomotion, drug reward, and drug-taking behaviors. On the other hand, environmental enrichment can produce a protective phenotype against drug-related behaviors. In this chapter, we discuss findings regarding consequences of social stress and environmental enrichment on sensitization to ethanol.