Young A R
Biochimie. 1986 Jun;68(6):885-9. doi: 10.1016/s0300-9084(86)80105-5.
8-Methoxypsoralen in combination with UVA radiation (PUVA) is carcinogenic in mice and probably so in man. PUVA is genotoxic and so has tumour initiation potential. Some evidence suggests that PUVA has other biological effects which may be equated with tumour promotion. Thus, the use of a two-stage model, similar to that of chemical carcinogenesis, may be a useful experimental approach for the further understanding of PUVA carcinogenesis.
8-甲氧基补骨脂素联合长波紫外线辐射（PUVA）对小鼠具有致癌性，对人类可能也是如此。PUVA具有基因毒性，因此具有引发肿瘤的潜力。一些证据表明，PUVA具有其他可能等同于肿瘤促进作用的生物学效应。因此，采用类似于化学致癌作用的两阶段模型，可能是进一步了解PUVA致癌作用的一种有用的实验方法。
