Kagan Iu S, Kokshareva N V, Tkachenko I I
Biull Eksp Biol Med. 1986 Sep;102(9):310-2.
The inhibition of neurotoxic esterase activity in chicken brain has been studied in vitro and in vivo. Aphos exposure, causing chicken paralysis, has demonstrated that the initial stage of delayed neurotoxicity was significant esterase activity inhibition (by 60-80%) within 3-24 hours after the pesticide administration. The inhibition of cholinesterase activity occurred both in the blood and sciatic nerve. The delayed conduction through peripheral nerves caused by demyelination has been revealed in the latent period (before the clinical signs of intoxication).
已在体外和体内研究了鸡脑中神经毒性酯酶活性的抑制情况。接触导致鸡麻痹的对氧磷表明，延迟性神经毒性的初始阶段是在施用农药后3至24小时内显著抑制酯酶活性（60%-80%）。血液和坐骨神经中均出现胆碱酯酶活性抑制。在潜伏期（中毒临床症状出现之前）已发现由脱髓鞘引起的外周神经传导延迟。
