Faull R L, Villiger J W
Brain Res. 1986 Aug 27;381(1):153-8. doi: 10.1016/0006-8993(86)90704-3.
The distribution of benzodiazepine receptors in the human striatum was studied by quantitative autoradiography following in vitro labelling of cryostat sections with [3H]flunitrazepam, and the pattern of receptor-labelling was compared to the distribution of acetylcholinesterase (AChE) staining in adjacent sections. A heterogeneous pattern of benzodiazepine receptors was found in all regions of the striatum. The highest densities of receptors were seen in the ventral striatum (nucleus accumbens and olfactory tubercle), where very dense receptor patches aligned with both AChE-poor and AChE-rich regions. The dorsal striatum (caudate nucleus and putamen) contained lower concentrations of benzodiazepine receptors, but dense receptor patches were still evident (especially in the caudate nucleus) and these aligned with AChE-poor striosomes.
采用[3H]氟硝西泮对冰冻切片进行体外标记后，通过定量放射自显影术研究了苯二氮䓬受体在人类纹状体中的分布，并将受体标记模式与相邻切片中乙酰胆碱酯酶（AChE）染色的分布进行了比较。在纹状体的所有区域均发现苯二氮䓬受体呈异质性分布。在腹侧纹状体（伏隔核和嗅结节）中观察到最高密度的受体，其中非常密集的受体斑块与AChE含量低和含量高的区域对齐。背侧纹状体（尾状核和壳核）中苯二氮䓬受体的浓度较低，但密集的受体斑块仍然明显（尤其是在尾状核中），并且这些斑块与AChE含量低的纹状小体对齐。
