Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Division of Allergy & Immunology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Perelman School of Medicine at The University of Pennsylvania, Philadelphia, Pennsylvania.
Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Division of Allergy & Immunology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Perelman School of Medicine at The University of Pennsylvania, Philadelphia, Pennsylvania.
Ann Allergy Asthma Immunol. 2018 Dec;121(6):711-716. doi: 10.1016/j.anai.2018.08.022. Epub 2018 Sep 6.
Previous reports suggest a higher prevalence of comorbid diseases in patients with eosinophilic esophagitis (EoE), although few have systematically quantified comorbidities in pediatric patients.
To define the rate of comorbid diagnoses in pediatric EoE patients compared with rates in those without EoE.
Retrospective cross-sectional review of electronic medical records for patients seen in a single large pediatric primary care network between January 2007 and December 2016 (n = 456,148). International Classification of Diseases, Ninth and Tenth Revision codes were used to determine prevalence rates for coexisting diagnoses.
A total of 428 patients held a diagnosis for EoE. Significant differences in rate of comorbid diseases included allergic rhinoconjunctivitis (60.0% of EoE cohort vs 17.4% of non-EoE cohort, P < .0001); asthma (59.8% of EoE, 21.4% of non-EoE, P < .0001); atopic dermatitis (17.8% of EoE, 6.6% of non-EoE, P < .0001); adrenal insufficiency (2.6% of EoE, 0.4% of non-EoE, P < .0001); autism spectrum disorder (7.5% of EoE, 1.9% of non-EoE, P < .0001); celiac disease (5.6% of EoE, 0.9% of non-EoE, P < .0001); connective tissue diseases (1.4% of EoE, 0.1% of non-EoE, P < .0001); cystic fibrosis (0.9% of EoE, 0.05% of non-EoE, P < .0001); inflammatory bowel disease (0.7% of EoE, 0.2% of non-EoE, P = .03); type 1 diabetes mellitus (1.2% of EoE, 0.3% of non-EoE, P = .0069).
Children with EoE have markedly higher rates of both atopic and non-atopic diseases compared with children without EoE. These associations have important implications for comprehensive EoE care and future research regarding associated disease mechanisms.
先前的报告表明，嗜酸细胞性食管炎（EoE）患者合并症的患病率较高，尽管少数研究已系统地量化了儿科患者的合并症。
与非 EoE 患者相比，确定儿科 EoE 患者合并诊断的发生率。
对 2007 年 1 月至 2016 年 12 月期间在单一大型儿科初级保健网络中就诊的 456148 例患者的电子病历进行回顾性横断面研究。使用国际疾病分类，第九和第十版代码确定共存诊断的患病率。
共有 428 例患者被诊断为 EoE。合并症发生率的显著差异包括过敏性鼻结膜炎（EoE 队列的 60.0%与非 EoE 队列的 17.4%，P<0.0001）；哮喘（EoE 队列的 59.8%与非 EoE 队列的 21.4%，P<0.0001）；特应性皮炎（EoE 队列的 17.8%与非 EoE 队列的 6.6%，P<0.0001）；肾上腺功能不全（EoE 队列的 2.6%与非 EoE 队列的 0.4%，P<0.0001）；自闭症谱系障碍（EoE 队列的 7.5%与非 EoE 队列的 1.9%，P<0.0001）；乳糜泻（EoE 队列的 5.6%与非 EoE 队列的 0.9%，P<0.0001）；结缔组织疾病（EoE 队列的 1.4%与非 EoE 队列的 0.1%，P<0.0001）；囊性纤维化（EoE 队列的 0.9%与非 EoE 队列的 0.05%，P<0.0001）；炎症性肠病（EoE 队列的 0.7%与非 EoE 队列的 0.2%，P=0.03）；1 型糖尿病（EoE 队列的 1.2%与非 EoE 队列的 0.3%，P=0.0069）。
与非 EoE 儿童相比，EoE 儿童的特应性和非特应性疾病发生率明显更高。这些关联对全面的 EoE 护理和未来与相关疾病机制相关的研究具有重要意义。
