Ramqvist T, Dalianis T, Reinholdsson G, Klein G, Szigeti R
Cancer Res. 1986 Oct;46(10):5045-8.
Soluble membrane fractions derived from polyoma tumor cells trigger lymphocytes, derived from polyoma-immunized animals, but not from nonimmunized controls, to release the lymphokine, macrophage migration-inhibitory factor. The reaction can be blocked by sera from polyoma-bearing animals. Absorption of these sera with polyoma cells, but not with nonpolyoma cell lines, abrogates this activity. These findings suggest that there is a polyoma virus-induced membrane component that can induce polyoma-specific macrophage migration inhibition.
源自多瘤肿瘤细胞的可溶性膜组分可触发来自经多瘤免疫动物而非未免疫对照动物的淋巴细胞释放淋巴因子——巨噬细胞移动抑制因子。该反应可被患多瘤动物的血清阻断。用多瘤细胞而非非多瘤细胞系吸收这些血清可消除此活性。这些发现表明存在一种多瘤病毒诱导的膜成分，其可诱导多瘤特异性巨噬细胞移动抑制。
