Neuroimmunology Unit, Medical School, The Faculty of Medicine and Life Sciences, Tampere University Hospital, University of Tampere, Tampere, Finland; Neuro Group, BioMeditech, The Faculty of Medicine and Life Sciences, University of Tampere, Finland.
Neuro Group, BioMeditech, The Faculty of Medicine and Life Sciences, University of Tampere, Finland.
J Neuroimmunol. 2019 Jun 15;331:36-45. doi: 10.1016/j.jneuroim.2018.07.010. Epub 2018 Aug 29.
Multiple Sclerosis (MS) is an inflammatory neurodegenerative disease, where neural progenitor cell (NPC) transplantation has been suggested as a potential neuroprotective therapeutic strategy. Since the effect of inflammation on NPCs is poorly known, their effect on the survival and functionality of human NPCs were studied. Treatment with interleukin (IL)-6, tumor necrosis factor (TNF)-α and interferon (IFN)-γ did not induced cytotoxicity, but IFN-γ treatment showed decreased proliferation and neuronal migration. By contrast, increased proliferation and inhibition of electrical activity were detected after TNF-α treatment. Treatments induced secretion of inflammatory factors. Inflammatory cytokines appear to modulate proliferation as well as the cellular and functional properties of human NPCs.
多发性硬化症（MS）是一种炎症性神经退行性疾病，神经祖细胞（NPC）移植被认为是一种潜在的神经保护治疗策略。由于炎症对 NPC 的影响知之甚少，因此研究了其对人 NPC 存活和功能的影响。白细胞介素（IL）-6、肿瘤坏死因子（TNF）-α和干扰素（IFN）-γ的处理并未诱导细胞毒性，但 IFN-γ处理显示增殖和神经元迁移减少。相比之下，TNF-α处理后检测到增殖增加和电活性抑制。处理诱导了炎症因子的分泌。炎症细胞因子似乎调节人 NPC 的增殖以及细胞和功能特性。
