Cox J D, Samson M K, Herskovic A M, Abrams R, Koehler M
Cancer Treat Rep. 1986 Oct;70(10):1219-20.
A trial of "neoadjuvant" cisplatin-etoposide and radiation therapy was conducted by the Radiation Therapy Oncology Group for non-small cell carcinoma of the lung limited to the thorax. Thirty evaluable patients were studied: two achieved complete response and four achieved partial response after chemotherapy. All patients underwent radiation therapy as planned, with no unusual acute reactions. Sixteen patients had local failure, and 13 had distant metastasis. Twenty-seven patients are dead, two are alive with cancer, and one is clinically free of cancer at 145 weeks. Five of six patients who survived greater than or equal to 2 years after treatment had adenocarcinomas. There was no unexpected late toxicity. This combination of chemotherapy and radiotherapy is unlikely to improve results in the treatment of inoperable non-small cell carcinoma of the lung over those with radiotherapy alone.
放射治疗肿瘤学组针对局限于胸部的非小细胞肺癌开展了一项“新辅助”顺铂-依托泊苷与放射治疗的试验。研究了30例可评估患者：化疗后2例达到完全缓解，4例达到部分缓解。所有患者均按计划接受了放射治疗，未出现异常急性反应。16例患者出现局部失败，13例出现远处转移。27例患者死亡，2例带癌生存，1例在145周时临床无癌。治疗后存活≥2年的6例患者中有5例为腺癌。未出现意外的晚期毒性。与单纯放疗相比，这种化疗与放疗的联合不太可能改善不可手术的非小细胞肺癌的治疗效果。
