1994 年至 2012 年人群研究中临床诊断的阿尔茨海默病痴呆的患病率和发病率。
Prevalence and incidence of clinically diagnosed Alzheimer's disease dementia from 1994 to 2012 in a population study.
机构信息
Department of Public Health Sciences, UC Davis, Davis, CA, USA.
Boston University School of Public Health, Department of Epidemiology, Boston, MA, USA.
出版信息
Alzheimers Dement. 2019 Jan;15(1):1-7. doi: 10.1016/j.jalz.2018.07.216. Epub 2018 Sep 7.
Abstract
INTRODUCTION
The trends in prevalence and incidence of Alzheimer's disease (AD) dementia remain uncertain.
METHODS
A sample of 2794 participants with a clinical diagnosis for AD dementia were included.
RESULTS
The 2010 census standardized prevalence of AD dementia was 14.5% (95% CI = 13.7-15.3), and annual incidence was 2.3% (1.7-2.9). Both prevalence and incidence showed substantial variation over time, but no secular trends. The prevalence of AD dementia did not change significantly from 14.6% (95% CI = 13.0, 16.2) in 1994-1997 to 14.7% (95% CI = 13.2, 16.2) in 2010-2012 (P = .84). The annual incidence of AD dementia was 2.8% (95% CI = 2.2, 3.2) in 1998-2000 and 2.2% (95% CI = 1.6, 2.8) in 2004-2006 (P = .20) and remained steady in 2010-2012. The prevalence and incidence among African Americans were approximately twice than those among European Americans.
CONCLUSIONS
The prevalence and incidence of AD dementia showed substantial variation between 1994 and 2012, but no secular trend.
摘要
简介
阿尔茨海默病（AD）痴呆的流行和发病趋势仍不确定。
方法
纳入了 2794 名临床诊断为 AD 痴呆的参与者。
结果
2010 年人口普查标准化 AD 痴呆患病率为 14.5%（95%CI=13.7-15.3），年发病率为 2.3%（1.7-2.9）。患病率和发病率均随时间有较大变化，但无长期趋势。AD 痴呆的患病率从 1994-1997 年的 14.6%（95%CI=13.0，16.2）到 2010-2012 年的 14.7%（95%CI=13.2，16.2）没有显著变化（P=0.84）。AD 痴呆的年发病率在 1998-2000 年为 2.8%（95%CI=2.2，3.2），在 2004-2006 年为 2.2%（95%CI=1.6，2.8），在 2010-2012 年保持稳定。非裔美国人的患病率和发病率大约是欧洲裔美国人的两倍。
结论
1994 年至 2012 年间，AD 痴呆的患病率和发病率有较大变化，但无长期趋势。
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