Wilson Leah C, Goodson James L, Kingsbury Marcy A
Department of Biology, Indiana University, Bloomington, IN 47405, USA.
Department of Biology, Indiana University, Bloomington, IN 47405, USA.
Physiol Behav. 2018 Nov 1;196:165-175. doi: 10.1016/j.physbeh.2018.09.002. Epub 2018 Sep 6.
The social behavior network, a collection of reciprocally connected areas within the basal forebrain and midbrain, plays a conserved role in the regulation of vertebrate social behavior. Specific behaviors are associated with patterns of activity across the network, and these activity profiles vary with species and context. We investigated how the social behavior network responds to familiar social stimuli in a seasonally flocking songbird. Further, we explored how socially-induced neural responses are modulated by endogenous nonapeptide receptor blockade. Winter flocking dark-eyed juncos were exposed to either familiar conspecifics or a familiar empty aviary following a peripheral injection of either saline or [desGly-NH,d(CH), Tyr(Me),Thr]-ornithine vasotocin, an VT3 receptor antagonist. Socially-exposed animals exhibited greater Fos induction across the social behavior network. Sex and drug effects were site-specific, with females tending to exhibit greater Fos responses to social stimuli and a greater sensitivity to VT3 antagonism. We suggest that in flocking animals, VT3 activation during social interaction may shift the pattern of neural activity towards the dorsocaudal lateral septum and rostral arcopallium and away from the extended amygdala, anterior and ventromedial hypothalamus, and the caudal ventral/ventrolateral lateral septum.
社会行为网络是基底前脑和中脑内相互连接区域的集合，在脊椎动物社会行为的调节中发挥着保守作用。特定行为与整个网络的活动模式相关，并且这些活动概况随物种和环境而变化。我们研究了社会行为网络如何在季节性群居的鸣禽中对熟悉的社会刺激做出反应。此外，我们探讨了内源性九肽受体阻断如何调节社会诱导的神经反应。在对外周注射生理盐水或[去甘氨酰胺，d(CH)，酪氨酸（甲基），苏氨酸]-鸟氨酸血管加压素（一种VT3受体拮抗剂）后，将冬季群居的暗眼灯草鹀暴露于熟悉的同种个体或熟悉的空鸟舍中。接受社会暴露的动物在整个社会行为网络中表现出更强的Fos诱导。性别和药物效应具有位点特异性，雌性往往对社会刺激表现出更强的Fos反应，并且对VT3拮抗作用更敏感。我们认为，在群居动物中，社交互动期间VT3的激活可能会使神经活动模式向背尾外侧隔区和嘴侧弓状皮质转移，远离扩展杏仁核、前下丘脑和腹内侧下丘脑以及尾侧腹侧/腹外侧外侧隔区。
