Miyachi Shigeru, Hiramatsu Ryo, Ohnishi Hiroyuki, Takahashi Kenkichi, Kuroiwa Toshihiko
Department of Neuroendovascular Therapy Center, Aichi Medical University, Nagakute, Japan.
Department of Neurosurgery and Endovascular Therapy, Osaka Medical College, Takatsuki, Japan.
Neurointervention. 2018 Sep;13(2):138-143. doi: 10.5469/neuroint.2018.00990. Epub 2018 Oct 1.
For many years, the pathophysiology of idiopathic intracranial hypertension (IIH) was interpreted as "secondary intracranial hypertension," and IIH was considered to be caused by brain edema due to obstructive sleep apnea. Another theory proposed cerebrospinal fluid (CSF) absorption impairment due to excessive medication with vitamin A derivatives. Other reports pointed out the importance of obesity, which may cause an impairment of intracranial venous drainage due to elevated right atrial pressure. Patients with medically refractory IIH have traditionally undergone a CSF diversion. Venous outlet impairment on IIH has recently been reported as a causative or contributory cause, and thus focused venoplasty of the stenotic sinus with a stent has emerged as a new treatment strategy. We report the cases of two patients who presented with headache and papilledema with IIH. They successfully underwent stent placement at the stenosis of the transverse sinus and experienced complete resolution of symptoms.
多年来,特发性颅内高压(IIH)的病理生理学被解释为“继发性颅内高压”,IIH被认为是由阻塞性睡眠呼吸暂停导致的脑水肿引起的。另一种理论提出,由于过量使用维生素A衍生物药物导致脑脊液(CSF)吸收受损。其他报告指出肥胖的重要性,肥胖可能由于右心房压力升高导致颅内静脉引流受损。传统上,药物治疗难治的IIH患者会接受脑脊液分流术。最近有报道称,IIH患者的静脉出口受损是一个致病或促成因素,因此,使用支架对狭窄窦进行聚焦静脉成形术已成为一种新的治疗策略。我们报告了两名表现为头痛和视乳头水肿的IIH患者的病例。他们在横窦狭窄处成功进行了支架置入,症状完全缓解。