Th17 通路特征在印度大样本吉兰-巴雷综合征患者中。
Th17 pathway signatures in a large Indian cohort of Guillain Barré syndrome.
机构信息
Department of Human Genetics, National Institute of Mental Health and Neurosciences, Bangalore 560029, India.
Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore 560029, India.
出版信息
J Neuroimmunol. 2018 Oct 15;323:125-130. doi: 10.1016/j.jneuroim.2018.08.001. Epub 2018 Aug 3.
The etiopathogenesis of Guillain Barré Syndrome (GBS) is inadequately understood. The role of immuno-inflammatory Th17 pathway was examined in GBS patients by genetic, gene expression and biochemical studies. Genotyping of G197A single nucleotide polymorphism within IL17 gene was carried out by PCR-RFLP method in 220 GBS patients. Quantification of gene expression of STAT3 and RORC and estimation of plasma level of IL-17A were carried out in a subset of patients. Significantly increased STAT3 gene expression in lymphocytes and plasma IL-17A levels were observed in GBS patients. This study adds new dimension and reinforces important implications of Th17 pathway in GBS.
吉兰-巴雷综合征（GBS）的病因发病机制尚不完全清楚。通过遗传、基因表达和生化研究，探讨了免疫炎症性 Th17 通路在 GBS 患者中的作用。采用 PCR-RFLP 法对 220 例 GBS 患者 IL17 基因内 G197A 单核苷酸多态性进行基因分型。对部分患者进行 STAT3 和 RORC 基因表达定量和血浆 IL-17A 水平测定。在 GBS 患者中观察到淋巴细胞 STAT3 基因表达和血浆 IL-17A 水平显著增加。本研究增加了新的维度，并强化了 Th17 通路在 GBS 中的重要意义。
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