Turk J L
Lymphology. 1977 Jun;10(2):46-53.
Organized lymphoid tissue is found in the thymus, spleen, lymph nodes; lining the respiratory and alimentary tracts; and also occurring at sites of chronic inflammation. Apart from the thymus which is involved in the regulation of T-cell function, the other tissues are organized into T-cell and B-cell areas. Lymphocytes in T-cell areas respond by proliferation in cell-mediated immunity and by the production of suppressor cells and helper for antibody formation. B-cell areas are involved in the humoral antibody response. B-cells are segregated into lymph follicles where they form germinal centers and are found at the corticomedullary junction where they differentiate into plasma cells. The role of lymph follicles in becoming germinal centers is poorly understood, but these areas are known to be the site of antigen trapping in primed animals. The particular function of the spleen as a localized area of lymphoid tissue along the course of the blood vascular system is discussed, particularly with respect to its ability to respond to soluble antigen released from sites of localized antigen deposition such as tumors.
有组织的淋巴组织见于胸腺、脾脏、淋巴结；呼吸道和消化道的内衬；以及慢性炎症部位。除了参与T细胞功能调节的胸腺外，其他组织被组织成T细胞区和B细胞区。T细胞区的淋巴细胞通过细胞介导免疫中的增殖以及产生抑制细胞和辅助抗体形成的细胞来做出反应。B细胞区参与体液抗体反应。B细胞被分隔到淋巴滤泡中，在那里它们形成生发中心，并位于皮质髓质交界处，在那里它们分化为浆细胞。淋巴滤泡形成生发中心的作用尚不清楚，但已知这些区域是致敏动物中抗原捕获的部位。脾脏作为沿血管系统分布的局部淋巴组织区域的特殊功能进行了讨论，特别是关于其对从局部抗原沉积部位（如肿瘤）释放的可溶性抗原做出反应的能力。
