School of Psychology, University of Ottawa, Canada; The Ottawa Hospital Research Institute, Canada.
School of Psychology, University of Ottawa, Canada; The Ottawa Hospital Research Institute, Canada; Psychology, The Ottawa Hospital, Canada; Faculty of Medicine, University of Ottawa, Canada.
J Cyst Fibros. 2019 Jan;18(1):150-157. doi: 10.1016/j.jcf.2018.08.008. Epub 2018 Sep 7.
Cystic Fibrosis (CF) is the most common genetic disease affecting children and young adults in Canada. It is a multi-system disease, however lung disease is largely responsible for mortality. Treatment advances have resulted in increased life expectancy and a subsequent need to better understand psychosocial issues associated with quality of life in adults living with CF. Emerging research suggests that anxiety and depression are related to poorer health-related quality of life (HRQoL) in CF patients, but there is little research examining cognitive processes, such as breathlessness catastrophizing. The present study addresses this gap in the literature.
Participants in this study are based on a convenience sample of patients recruited during their regular CF clinic appointments at a tertiary care center. Forty-five adults (M = 30.73 years) completed measures of lung function, depression, anxiety, pain, breathlessness catastrophizing, and HRQoL at one time point.
Results of a hierarchical multiple regression indicate that increased breathlessness catastrophizing was related to poorer HRQoL, after controlling for lung function, depression, anxiety, and pain (p < .05). Depression, pain, and breathlessness catastrophizing all emerged as significant unique predictors of HRQoL.
Breathlessness catastrophizing is a potential target for clinical intervention and might impact HRQoL. Further research on breathlessness catastrophizing in CF is warranted including longitudinal studies to examine the mechanisms by which breathlessness catastrophizing relates to HRQoL and treatment outcomes in CF.
囊性纤维化（CF）是加拿大影响儿童和年轻人的最常见遗传疾病。它是一种多系统疾病，但肺部疾病是导致死亡的主要原因。治疗进展导致预期寿命延长，因此需要更好地了解与 CF 成人生活质量相关的社会心理问题。新出现的研究表明，焦虑和抑郁与 CF 患者的健康相关生活质量（HRQoL）较差有关，但很少有研究检查认知过程，例如呼吸困难灾难化。本研究弥补了这一文献空白。
本研究的参与者基于在三级护理中心的常规 CF 诊所就诊时招募的方便样本。45 名成年人（M = 30.73 岁）一次完成了肺功能、抑郁、焦虑、疼痛、呼吸困难灾难化和 HRQoL 的测量。
分层多元回归的结果表明，在控制肺功能、抑郁、焦虑和疼痛后，呼吸困难灾难化程度增加与 HRQoL 较差相关（p <.05）。抑郁、疼痛和呼吸困难灾难化都是 HRQoL 的显著独立预测因素。
呼吸困难灾难化是临床干预的潜在目标，可能会影响 HRQoL。需要对 CF 中的呼吸困难灾难化进行进一步研究，包括纵向研究，以检验呼吸困难灾难化与 CF 中 HRQoL 和治疗结果的关系机制。
