Theodorou A E, Hale A S, Davies S L, Katona C L, Yamaguchi Y, Horton R W, Kelly J S, Paykel E S
Eur J Pharmacol. 1986 Jul 31;126(3):329-32. doi: 10.1016/0014-2999(86)90067-1.
Increased numbers of platelet high affinity alpha 2-adrenoceptors binding sites have been reported in depressed patients using the agonist radioligand [3H]clonidine, whereas no differences from controls have been found using antagonist radioligands. We have measured platelet high affinity alpha 2-adrenoceptors in 13 depressed patients and 14 well-matched controls using a new selective agonist radioligand, [3H]UK-14,304. Unlike previous studies using [3H]clonidine, we find no differences in Bmax or KD of the high affinity alpha 2-adrenoceptor binding sites between the 2 groups.
