Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA; Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Cell Metab. 2019 Jan 8;29(1):221-228.e3. doi: 10.1016/j.cmet.2018.08.011. Epub 2018 Sep 6.
The importance of dietary composition and feeding patterns in aging remains largely unexplored, but was implicated recently in two prominent nonhuman primate studies. Here, we directly compare in mice the two diets used in the primate studies focusing on three paradigms: ad libitum (AL), 30% calorie restriction (CR), and single-meal feeding (MF), which accounts for differences in energy density and caloric intake consumed by the AL mice. MF and CR regimes enhanced longevity regardless of diet composition, which alone had no significant impact within feeding regimens. Like CR animals, MF mice ate quickly, imposing periods of extended daily fasting on themselves that produced significant improvements in morbidity and mortality compared with AL. These health and survival benefits conferred by periods of extended daily fasting, independent of dietary composition, have major implications for human health and clinical applicability.
饮食组成和喂养模式在衰老过程中的重要性在很大程度上仍未得到探索，但最近在两项重要的非人类灵长类动物研究中被涉及。在这里，我们直接比较了在这两项灵长类动物研究中使用的两种饮食，重点关注三个范式：随意进食（AL）、30%热量限制（CR）和单餐喂养（MF），这考虑到了 AL 小鼠所消耗的能量密度和卡路里摄入量的差异。MF 和 CR 方案无论饮食组成如何都能延长寿命，而单独的饮食组成在喂养方案中没有显著影响。与 CR 动物一样，MF 小鼠进食迅速，使自己每天长时间禁食，与 AL 相比，这显著改善了发病率和死亡率。这种由延长的每日禁食带来的健康和生存益处，与饮食组成无关，对人类健康和临床应用具有重大意义。
