生酮饮食可降低中年死亡率并改善衰老小鼠的记忆。
Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice.
机构信息
Buck Institute for Research on Aging, Novato, CA 94945, USA; UCSF Division of Geriatrics, San Francisco, CA 94118, USA; Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA.
Buck Institute for Research on Aging, Novato, CA 94945, USA.
出版信息
Cell Metab. 2017 Sep 5;26(3):547-557.e8. doi: 10.1016/j.cmet.2017.08.004.
Ketogenic diets recapitulate certain metabolic aspects of dietary restriction such as reliance on fatty acid metabolism and production of ketone bodies. We investigated whether an isoprotein ketogenic diet (KD) might, like dietary restriction, affect longevity and healthspan in C57BL/6 male mice. We find that Cyclic KD, KD alternated weekly with the Control diet to prevent obesity, reduces midlife mortality but does not affect maximum lifespan. A non-ketogenic high-fat diet (HF) fed similarly may have an intermediate effect on mortality. Cyclic KD improves memory performance in old age, while modestly improving composite healthspan measures. Gene expression analysis identifies downregulation of insulin, protein synthesis, and fatty acid synthesis pathways as mechanisms common to KD and HF. However, upregulation of PPARα target genes is unique to KD, consistent across tissues, and preserved in old age. In all, we show that a non-obesogenic ketogenic diet improves survival, memory, and healthspan in aging mice.
生酮饮食重现了饮食限制的某些代谢方面，如依赖脂肪酸代谢和酮体的产生。我们研究了一种等蛋白生酮饮食（KD）是否可以像饮食限制一样影响 C57BL/6 雄性小鼠的寿命和健康跨度。我们发现，周期性 KD（KD 与对照饮食每周交替以防止肥胖）可降低中年死亡率，但不影响最大寿命。类似地，一种非生酮高脂肪饮食（HF）可能对死亡率有中等影响。周期性 KD 可改善老年时的记忆表现，同时适度改善综合健康跨度指标。基因表达分析确定了胰岛素、蛋白质合成和脂肪酸合成途径的下调是 KD 和 HF 的共同机制。然而，PPARα 靶基因的上调是 KD 所特有的，在所有组织中都存在，并在老年时得以保留。总之，我们表明，一种非肥胖生酮饮食可改善衰老小鼠的生存、记忆和健康跨度。
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