Jiang Chengzhi, Li Xinhui, Dend Haoyu, Liu Jinyan, Huang Jin, Liu Dan, Xu Xueliang
Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2018 Aug 28;43(8):869-874. doi: 10.11817/j.issn.1672-7347.2018.08.008.
To compare diagnostic value of 4 kinds of target-to-nontarget ratio (T/NT), and to choose a better one to assess thyroid associated ophthalmopathy (TAO) activity. Methods: The clinical data were collected for 29 newly-diagnosed patients (58 eyes) with TAO who underwent orbital 99mTc-DTPA single photon emission computed tomography/computed tomography (SPECT/CT) fusion images according to the clinical activity score (CAS). They were divided into an active group (18 cases, 36 eyes), an inactive group (11 cases, 22 eyes), and a control group (9 cases, 18 eyes). Diagnostic value of orbital/occipital lobe radioactive uptake count ratio (T/NT1), orbital/occipital radioactive uptake count ratio (T/NT2), orbital/thalamus radioactive uptake count ratio (T/NT3), and orbital/cerebellar radioactivity uptake count ratio (T/NT4) were calculated, and the CAS of Spearman rank correlation and receiver operating characteristic (ROC) curve were analyzed. Results: T/NT1, T/NT2 and CAS were correlated (r1=0.873, r2=0.527; P<0.001), with the better correlation between T/NT1 and CAS and there was no correlation between T/NT3, T/NT4 and CAS (r3=0.039, r4=0.090; P>0.05). Area under the ROC curve of T/NT1 was 0.860, area under the ROC curve of T/NT2 was 0.581, and the accuracy for T/NT1 on TAO activity was good. T/NT1=9.74 could be used as active threshold for judge of TAO in patients. Conclusion: There is a good correlation between T/NT1 and CAS. TAO activity assessment possesses high diagnostic value, and SPECT/CT together with imaging anatomical location is more accurate.
比较4种靶与非靶比值（T/NT）的诊断价值，选择一种更好的指标来评估甲状腺相关性眼病（TAO）的活动度。方法：收集29例新诊断的TAO患者（58只眼）的临床资料，这些患者根据临床活动度评分（CAS）接受了眼眶99mTc-DTPA单光子发射计算机断层扫描/计算机断层扫描（SPECT/CT）融合显像。将他们分为活动组（18例，36只眼）、非活动组（11例，22只眼）和对照组（9例，18只眼）。计算眼眶/枕叶放射性摄取计数比值（T/NT1）、眼眶/枕部放射性摄取计数比值（T/NT2）、眼眶/丘脑放射性摄取计数比值（T/NT3）和眼眶/小脑放射性摄取计数比值（T/NT4）的诊断价值，并分析其与CAS的Spearman等级相关性及受试者操作特征（ROC）曲线。结果：T/NT1、T/NT2与CAS相关（r1=0.873，r2=0.527；P<0.001），T/NT1与CAS的相关性更好，T/NT3、T/NT4与CAS无相关性（r3=0.039，r4=0.090；P>0.05）。T/NT1的ROC曲线下面积为0.860，T/NT2的ROC曲线下面积为0.581，T/NT1对TAO活动度的诊断准确性良好。T/NT1=9.74可作为判断TAO患者活动度的阈值。结论：T/NT1与CAS有良好的相关性。TAO活动度评估具有较高的诊断价值，SPECT/CT结合影像解剖定位更准确。
