Lo Gullo A, Talotta R, Atteritano M
Department of Clinical and Experimental Medicine, University of Messina, 98124 Messina, Italy.
Open Rheumatol J. 2018 Aug 29;12:125-128. doi: 10.2174/1874312901812010125. eCollection 2018.
Aseptic osteonecrosis of the hip is a clinical entity in which the necrotic process of the bone leads to pain and progressive disability.
Pamidronate seems to reduce drastically the activation of the osteoclasts so that it can be useful only in the early stage of the disease, delaying the time of bone collapsing.
A 27-years-old male was treated with pamidronate for three consecutive days every four weeks.
After three months the patient came back at control showing a marked improvement in clinical condition, referred full recover from pain and dysmotility with improvement of the quality of life, which was confirmed by the result of MRI he had for control.
We reported a case of aseptic osteonecrosis of the hip which was successfully treated pamidronate at dosage of 45 mg.
髋部无菌性骨坏死是一种临床病症，其中骨坏死过程会导致疼痛和进行性残疾。
帕米膦酸盐似乎能大幅降低破骨细胞的活性，因此它可能仅在疾病早期有用，可延迟骨塌陷时间。
一名27岁男性每四周连续三天接受帕米膦酸盐治疗。
三个月后患者复诊，临床状况显著改善，自述疼痛和运动障碍完全恢复，生活质量提高，MRI检查结果证实了这一点。
我们报告了一例髋部无菌性骨坏死病例，该病例以45毫克的剂量使用帕米膦酸盐成功治愈。
