Quraishi Sadeq A, Camargo Carlos A
Vitamin D In Stress (ViDIS) Laboratory, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, 5 Fruit Street, GRJ 402, Boston, MA 02114, USA,
Emergency Medicine Network (EMNet) Coordinating Center, Department of Emergency Medicine, Massachusetts General Hospital, 326 Cambridge St, Suite 410, Boston, MA 02114,
J Restor Med. 2012 Sep;1(1):9-23. doi: 10.14200/jrm.2012.1.1001.
To review the current literature regarding vitamin D insufficiency and supplementation in major illnesses.
We reviewed Pubmed-indexed, English language manuscripts from January, 2003 to June, 2012 using search terms related to vitamin D, all-cause mortality, cardiovascular disease, pulmonary disease, diabetes mellitus, and cancer.
Incidence of disease, risk ratios associated with 25-hydroxyvitamin D [25(OH)D] levels, and/or vitamin D supplementation schedules were documented.
Although 25(OH)D levels ≥20 ng/mL were often associated with improved health outcomes, evidence suggests that 25(OH)D levels ≥30 ng/mL may confer additional health benefits.
Based on the available evidence, vitamin D supplementation to restore 25(OH)D levels within a range of 30-50 ng/mL is reasonable in order to optimize potential benefits and minimize potential risks. This, of course, should be considered in the context of individual patient needs and co-morbidities.
回顾关于重大疾病中维生素D缺乏及补充的当前文献。
我们使用与维生素D、全因死亡率、心血管疾病、肺部疾病、糖尿病和癌症相关的检索词，回顾了2003年1月至2012年6月在PubMed索引的英文手稿。
记录疾病发病率、与25-羟维生素D[25(OH)D]水平相关的风险比和/或维生素D补充方案。
虽然25(OH)D水平≥20 ng/mL通常与改善健康结果相关，但有证据表明25(OH)D水平≥30 ng/mL可能带来额外的健康益处。
基于现有证据，补充维生素D以使25(OH)D水平恢复到30 - 50 ng/mL范围内是合理的，以便优化潜在益处并最小化潜在风险。当然，这应根据个体患者的需求和合并症来考虑。
