Thuraisingam Thusanth, Mirmirani Paradi
Division of Dermatology, McGill University, Montreal, QC, Canada.
The Permanente Medical Group, Vallejo, CA.
Skin Appendage Disord. 2018 Aug;4(3):180-186. doi: 10.1159/000484488. Epub 2017 Nov 25.
Erosive pustular dermatosis (EPD) is a rare condition of the scalp and legs that is marked by crusted erosions or superficial ulcerations that may result in scarring alopecia and chronic wounds. The condition predominantly affects elderly female as compared to male patients. Its pathogenesis remains poorly understood. The majority of the cases in the literature are from the United Kingdom and continental Europe. In this series, we present 8 North American patients with EPD of the scalp, one of whom also had involvement of the legs and another with the involvement of the face. All our patients were advanced in age and had a predisposition to chronic actinic damage, which are common characteristics of EPD previously reported in the literature. We hypothesize that immunosenescence leads to an aberrant immune response to wound healing and, along with other factors such as a loss of the normal epidermal barrier, ultraviolet damage, and hormonal factors, may contribute to the development of this condition.
糜烂性脓疱性皮肤病（EPD）是一种罕见的头皮和腿部疾病，其特征为结痂性糜烂或浅表溃疡，可能导致瘢痕性脱发和慢性伤口。与男性患者相比，该疾病主要影响老年女性。其发病机制仍知之甚少。文献中的大多数病例来自英国和欧洲大陆。在本系列中，我们介绍了8例北美头皮EPD患者，其中1例腿部也受累，另1例面部受累。我们所有的患者年龄较大，且易患慢性光化性损伤，这是文献中先前报道的EPD的常见特征。我们推测免疫衰老会导致对伤口愈合的异常免疫反应，并且与其他因素如正常表皮屏障的丧失、紫外线损伤和激素因素一起，可能促成这种疾病的发生。
