Dermatology, Venereology and Andrology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Int J Dermatol. 2019 Feb;58(2):205-209. doi: 10.1111/ijd.14217. Epub 2018 Sep 9.
Psoriasis is a distressing chronic skin disease. Its exact pathogenesis is still unclear, as many factors interplay in its occurrence.
The aim of the study is to estimate elafin levels in the serum of both cases and controls and to correlate the levels with psoriasis severity and other markers of inflammation.
Twenty-six psoriatic cases along with 26 healthy controls were assigned in this case-control study. Psoriasis severity was determined by Psoriasis Area and Severity Index score. Elafin levels were measured by ELISA in serum of both cases and controls. C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were measured in the cases.
Elafin levels show highly statistical significance difference (P < 0.001) between cases and controls. There is a statistical significant correlation between elafin levels and both psoriasis severity and inflammation markers as CRP and ESR.
Elafin represents a mirror for psoriasis severity and inflammatory state.
银屑病是一种令人痛苦的慢性皮肤病。其确切的发病机制仍不清楚，因为许多因素在其发生中相互作用。
本研究旨在评估病例组和对照组血清中的弹性蛋白酶抑制剂水平，并将其与银屑病严重程度和其他炎症标志物进行相关性分析。
在这项病例对照研究中，我们将 26 例银屑病患者和 26 例健康对照者进行了分组。通过银屑病面积和严重程度指数评分来确定银屑病的严重程度。通过酶联免疫吸附试验（ELISA）测量血清中的弹性蛋白酶抑制剂水平。在病例组中测量 C 反应蛋白（CRP）和红细胞沉降率（ESR）。
病例组和对照组之间的弹性蛋白酶抑制剂水平存在高度统计学显著性差异（P<0.001）。弹性蛋白酶抑制剂水平与银屑病严重程度和炎症标志物如 CRP 和 ESR 之间存在统计学显著相关性。
弹性蛋白酶抑制剂反映了银屑病的严重程度和炎症状态。
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