99mTc标记的双功能螯合剂（DTS）放射性药物的研究：官能团在心肌摄取中的作用

Search for 99mTc labeled DTS bifunctional radiopharmaceutical: role of functional groups in myocardial accumulation.

作者信息

Hosotani T, Yokoyama A, Arano Y, Horiuchi K, Saji H, Torizuka K

出版信息

Int J Rad Appl Instrum A. 1986;37(6):505-11. doi: 10.1016/0883-2889(86)90156-5.

PMID:3019950

Abstract

Development of 99mTc-bifunctional radiopharmaceutical (BR) is attracting the interest of various research groups. In the present paper, various molecules containing a neutral 99mTc-dithiosemicarbazone (DTS) structure as the technetium chelating site, along with various functional groups (amino, carboxyl or isobutyl group with diverse charge) are tested for their chemical or biological functions. The study on the effect of those functional groups is carried out in vitro and in vivo. The validity of introducing an amino group along with the technetium chelating site DTS for myocardial accumulation is discussed.

摘要

99mTc双功能放射性药物（BR）的研发正吸引着各个研究团队的关注。在本文中，测试了各种含有中性99mTc-二硫代半卡巴腙（DTS）结构作为锝螯合位点，并带有各种官能团（电荷各异的氨基、羧基或异丁基）的分子的化学或生物学功能。对这些官能团作用的研究在体外和体内进行。讨论了在锝螯合位点DTS引入氨基以实现心肌聚集的有效性。