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48例慢性肠道假性梗阻的病因及预后：一项10年回顾性病例系列研究

Causes and prognosis of chronic intestinal pseudo-obstruction in 48 subjects: A 10-year retrospective case series.

作者信息

Lu Wei, Xiao Yongtao, Huang Jianhu, Lu Lina, Tao Yiqing, Yan Weihui, Cao Yi, Cai Wei

机构信息

Department of Pediatric Surgery, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai Institute for Pediatric Research Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China.

出版信息

Medicine (Baltimore). 2018 Sep;97(36):e12150. doi: 10.1097/MD.0000000000012150.

DOI:10.1097/MD.0000000000012150
PMID:30200110
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6133590/
Abstract

The aim of the study was to evaluate the prognosis and survival of pediatric subjects with chronic intestinal pseudo-obstruction (CIPO) and investigate the independent risk factors affecting their prognosis.This was a retrospective case series of all pediatric subjects suffering from CIPO and treated at the Pediatric Surgical ward of Xinhua Hospital between January 2006 and January 2016.The overall mortality was 19/48 (39.6%). Because of delayed CIPO diagnosis, many subjects underwent a variety of surgical procedures. The rate of additional surgical procedures was high (35/48, 72.9%), but the number of surgical procedures, parenteral nutrition, and megacystis did not affect mortality. Mycotic infection was significantly associated with mortality, while onset at <1 year and hypoganglionosis showed a tendency to be associated with mortality.Mycotic infection was associated with mortality of children with CIPO. Despite improving treatment approaches, the overall prognosis of CIPO remains poor. The choice of the surgical intervention could be based on standard criteria.

摘要

本研究旨在评估慢性肠假性梗阻（CIPO）患儿的预后和生存情况，并调查影响其预后的独立危险因素。这是一项对2006年1月至2016年1月期间在新华医院小儿外科病房接受治疗的所有CIPO患儿进行的回顾性病例系列研究。总死亡率为19/48（39.6%）。由于CIPO诊断延迟，许多患儿接受了各种手术。再次手术率很高（35/48，72.9%），但手术次数、肠外营养和巨膀胱并不影响死亡率。真菌感染与死亡率显著相关，而发病年龄<1岁和神经节减少症有与死亡率相关的趋势。真菌感染与CIPO患儿的死亡率相关。尽管治疗方法有所改进，但CIPO的总体预后仍然很差。手术干预的选择可基于标准标准。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8a1/6133590/98b8ce49b579/medi-97-e12150-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8a1/6133590/bb8a7fbabb9c/medi-97-e12150-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8a1/6133590/64219bdcf417/medi-97-e12150-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8a1/6133590/98b8ce49b579/medi-97-e12150-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8a1/6133590/bb8a7fbabb9c/medi-97-e12150-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8a1/6133590/64219bdcf417/medi-97-e12150-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8a1/6133590/98b8ce49b579/medi-97-e12150-g006.jpg

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