College of Pharmacy, Nova Southeastern University, Davie, FL 33328, USA.
Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia.
Int J Environ Res Public Health. 2018 Sep 1;15(9):1904. doi: 10.3390/ijerph15091904.
Individuals with diabetes are twice as likely to struggle from depressive symptoms than individuals without diabetes. However, this joint condition is undertreated in nearly two-thirds of patients. Failure to monitor the comorbidity may lead to suboptimal therapy. This study evaluated the association of antidepressant use with healthcare utilization in a national sample of patients with type 2 diabetes and depression symptoms in the United States. It further assessed the differences in sociodemographic, clinical, and behavioral factors between those who use antidepressants and those who do not. This study was a secondary data analysis using the National Health and Nutrition Examination Survey (NHANES) for the period 2005⁻2014. To assess if there were significant differences in sociodemographic, clinical, and behavioral factors between those who were taking antidepressants or not, Chi Square and independent t-tests were used. To assess if there was a significant association between antidepressant use and healthcare utilization, univariate and multivariate regression analyses were conducted. Of the 955 participants, only 33% were on antidepressants. There were significant differences in sociodemographic, clinical, and behavioral factors among those who used antidepressants and those who did not. Regardless of antidepressant use, the study population had access to health care. Those on antidepressants had fewer diabetes specialists' visits and more mental health care. There might be underlying health care disparities related to the use of, and access to, antidepressants. Further studies are needed to comprehensively explore the management of these comorbidities.
患有糖尿病的个体出现抑郁症状的可能性是没有糖尿病个体的两倍。然而，这种合并症在近三分之二的患者中治疗不足。未能监测合并症可能导致治疗效果不佳。本研究在美国患有 2 型糖尿病和抑郁症状的全国样本中评估了使用抗抑郁药与医疗保健利用之间的关联。它进一步评估了使用抗抑郁药和不使用抗抑郁药的患者在社会人口统计学、临床和行为因素方面的差异。本研究是使用 2005-2014 年国家健康和营养检查调查（NHANES）进行的二次数据分析。为了评估在使用抗抑郁药和不使用抗抑郁药的患者之间是否存在社会人口统计学、临床和行为因素方面的显著差异，使用了卡方检验和独立 t 检验。为了评估抗抑郁药使用与医疗保健利用之间是否存在显著关联，进行了单变量和多变量回归分析。在 955 名参与者中，只有 33%的人服用抗抑郁药。使用抗抑郁药和不使用抗抑郁药的患者在社会人口统计学、临床和行为因素方面存在显著差异。无论是否使用抗抑郁药，研究人群都能获得医疗保健。使用抗抑郁药的患者糖尿病专家就诊次数较少，心理健康护理次数较多。可能存在与使用和获得抗抑郁药相关的潜在医疗保健差异。需要进一步的研究来全面探索这些合并症的管理。
