Ma Ting-Yu, Xiang Li, Zhang Dong, Shi Yu-Hua, Ding Dan-Dan, Shen Xiao-Feng, Chen Shi-Lin
Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Zhongguo Zhong Yao Za Zhi. 2018 Aug;43(15):3041-3050. doi: 10.19540/j.cnki.cjcmm.2018.0093.
Malaria is one of the three most deadly diseases in the world. Artemisinin is the first line and effective drug for treating malaria, and only can be extracted from Artemisia annua. Therefore, it is of great significance to cultivate new varieties of A. annua with high artemisinin content. Based on the germplasm bank and the whole genome, transcriptome and genetic map, the authors can explore high-quality genes, stress-resistant genes and genetic markers which have been used for rapid breeding of superior varieties of A. annua. So these methods of molecular breeding will become the main breeding direction of A. annua in the future. The breeding times of new varieties of A. annua can be shortened with molecular breeding technology. Based on the genetic background and the current situation of molecular breeding of A. annua, the strategy and technical route of molecular breeding were discussed and worked out in this paper, which provided a guidance and scientific reference for molecular breeding of A. annua in the future.
疟疾是世界上三大最致命疾病之一。青蒿素是治疗疟疾的一线有效药物,且只能从黄花蒿中提取。因此,培育青蒿素含量高的黄花蒿新品种具有重要意义。基于种质库以及全基因组、转录组和遗传图谱,作者能够探索出用于黄花蒿优良品种快速育种的优质基因、抗逆基因和遗传标记。所以这些分子育种方法将成为未来黄花蒿的主要育种方向。利用分子育种技术可以缩短黄花蒿新品种的育种时间。本文基于黄花蒿的遗传背景和分子育种现状,探讨并制定了分子育种的策略和技术路线,为今后黄花蒿的分子育种提供了指导和科学参考。