Sharma Abha, Adams Colby, Cashdollar Benjamin D, Li Zheng, Nguyen Nam V, Sai Himasri, Shi Jiachun, Velchuru Gautham, Zhu Kevin Z, Pollack Gerald H
Department of Bioengineering, University of Washington, Seattle, WA, USA.
Dose Response. 2018 Sep 3;16(3):1559325818796937. doi: 10.1177/1559325818796937. eCollection 2018 Jul-Sep.
It is now well-confirmed that hydrophilic surfaces including those within the cell generate structural changes in water. This interfacial water is ordered and acquires features different from the bulk. Amongst those features is the exclusion of colloidal and molecular solutes from extensive regions next to the hydrophilic surface, thereby earning it the label of "exclusion zone" (EZ) water. The transition of ordered EZ water to bulk serves as an important trigger of many cellular physiological functions, and in turn cellular health. We tested physiological doses of half a dozen agents generally identified to restore or build health on the extent to which they build EZs. All agents known to enhance biological function resulted in EZ expansion. On the other hand, the weed killer, glyphosate, considerably diminished EZ size. While the expansion effect of the health-promoting agents was observed over a wide range of concentrations, excessive doses ultimately reduced EZ size. We hypothesize that EZ buildup may be a mechanistic feature underlying many health-promoting agents, while agents that impair health may act by diminishing the amount of EZ water.
现在已经充分证实，包括细胞内表面在内的亲水性表面会使水产生结构变化。这种界面水是有序的，具有与本体水不同的特性。这些特性之一是在亲水性表面附近的大片区域排除胶体和分子溶质，因此它被称为“排斥区”（EZ）水。有序的EZ水向本体水的转变是许多细胞生理功能以及细胞健康的重要触发因素。我们测试了六种通常被认为能恢复或增进健康的药剂的生理剂量，看它们在构建EZ方面的程度。所有已知能增强生物功能的药剂都会导致EZ扩大。另一方面，除草剂草甘膦会显著减小EZ的大小。虽然在很宽的浓度范围内都观察到了促进健康的药剂的扩大效应，但过量剂量最终会减小EZ的大小。我们推测，EZ的形成可能是许多促进健康的药剂的一个机制特征，而损害健康的药剂可能是通过减少EZ水的量来起作用的。
