一种用于研究骨关节炎进展和治疗的功能性组织工程化滑膜模型。
A Functional Tissue-Engineered Synovium Model to Study Osteoarthritis Progression and Treatment.
机构信息
1 Department of Biomedical Engineering, Columbia University , New York, New York.
2 Department of Orthopedic Surgery, Columbia University , New York, New York.
出版信息
Tissue Eng Part A. 2019 Apr;25(7-8):538-553. doi: 10.1089/ten.TEA.2018.0142. Epub 2018 Oct 31.
Abstract
The synovium envelops the diarthrodial joint and plays a key regulatory role in defining the composition of the synovial fluid through filtration and biosynthesis of critical boundary lubricants. Synovium changes often precede cartilage damage in osteoarthritis. We describe a novel tissue engineered model, validated against native synovium explants, to investigate the structure-function of synovium through quantitative solute transport measures. Synovium was evaluated in the presence of a proinflammatory cytokine, interleukin-1, or the clinically relevant corticosteroid, dexamethasone. We anticipate that a better understanding of synovium transport would support efforts to develop more effective strategies aimed at restoring joint health.
摘要
滑膜包绕着动关节，通过过滤和生物合成关键的边界润滑剂，在定义滑液成分方面发挥着关键的调节作用。滑膜变化往往先于骨关节炎的软骨损伤。我们描述了一种新的组织工程模型，该模型通过定量溶质传输测量来验证对天然滑膜外植体的结构-功能，在促炎细胞因子白细胞介素-1或临床相关的皮质类固醇地塞米松存在的情况下评估滑膜。我们预计，对滑膜转运的更好理解将支持开发更有效的策略，旨在恢复关节健康。
相似文献
1
A Functional Tissue-Engineered Synovium Model to Study Osteoarthritis Progression and Treatment.
Tissue Eng Part A. 2019 Apr;25(7-8):538-553. doi: 10.1089/ten.TEA.2018.0142. Epub 2018 Oct 31.
2
Inflammatory cytokines and mechanical injury induce post-traumatic osteoarthritis-like changes in a human cartilage-bone-synovium microphysiological system.
Arthritis Res Ther. 2022 Aug 18;24(1):198. doi: 10.1186/s13075-022-02881-z.
3
[Expression of interleukin-1beta and tumor necrosis factor-alpha in the synovium and synovial fluid of patients with Kashin-Beck disease and osteoarthritis].
Nan Fang Yi Ke Da Xue Xue Bao. 2009 Jan;29(1):5-8.
4
The Synovium of Human Osteoarthritic Joints Retains Its Chondrogenic Potential Irrespective of Age.
Tissue Eng Part A. 2022 Mar;28(5-6):283-295. doi: 10.1089/ten.TEA.2021.0105. Epub 2021 Dec 27.
5
Cytokine and catabolic enzyme expression in synovium, synovial fluid and articular cartilage of naturally osteoarthritic equine carpi.
Equine Vet J. 2010 Nov;42(8):693-9. doi: 10.1111/j.2042-3306.2010.00140.x. Epub 2010 Sep 14.
6
Production of catabolin by synovium from an experimental model of osteoarthritis.
J Orthop Res. 1989;7(4):519-29. doi: 10.1002/jor.1100070409.
7
Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase.
Arthritis Rheum. 1998 Jul;41(7):1275-86. doi: 10.1002/1529-0131(199807)41:7<1275::AID-ART19>3.0.CO;2-T.
8
Overexpression of cystatin C in synovium does not reduce synovitis or cartilage degradation in established osteoarthritis.
Arthritis Res Ther. 2015 Jan 16;17(1):5. doi: 10.1186/s13075-015-0519-3.
9
Chondroprotective and anti-inflammatory effects of S-methylisothiourea, an inducible nitric oxide synthase inhibitor in cartilage and synovial explants model of osteoarthritis.
J Pharm Pharmacol. 2014 Jul;66(7):1021-31. doi: 10.1111/jphp.12228. Epub 2014 Feb 20.
10
Transient anabolic effects of synovium in early post-traumatic osteoarthritis: a novel ex vivo joint tissue co-culture system for investigating synovium-chondrocyte interactions.
Osteoarthritis Cartilage. 2021 Jul;29(7):1060-1070. doi: 10.1016/j.joca.2021.03.010. Epub 2021 Mar 21.
引用本文的文献
1
Synovial Organoids and Cell Culture Models: An Ideal Platform for Exploring Traditional Chinese Medicine in Rheumatoid Arthritis.
ACS Omega. 2025 Aug 12;10(33):36904-36916. doi: 10.1021/acsomega.5c06035. eCollection 2025 Aug 26.
2
Effect of Blood on Synovial Joint Tissues: Potential Role of Ferroptosis.
Appl Sci (Basel). 2024 Jul 2;14(14). doi: 10.3390/app14146292. Epub 2024 Jul 19.
3
Synovium friction properties are influenced by proteoglycan content.
J Biomech. 2024 Sep;174:112272. doi: 10.1016/j.jbiomech.2024.112272. Epub 2024 Aug 10.
4
inflammatory multi-cellular model of osteoarthritis.
Osteoarthr Cartil Open. 2024 Jan 5;6(1):100432. doi: 10.1016/j.ocarto.2023.100432. eCollection 2024 Mar.
5
Modulating mechanobiology as a therapeutic target for synovial fibrosis to restore joint lubrication.
Osteoarthritis Cartilage. 2024 Jan;32(1):41-51. doi: 10.1016/j.joca.2023.09.012. Epub 2023 Oct 20.
6
Immature bovine cartilage wear is due to fatigue failure from repetitive compressive forces and not reciprocating frictional forces.
Osteoarthritis Cartilage. 2023 Dec;31(12):1594-1601. doi: 10.1016/j.joca.2023.08.008. Epub 2023 Aug 24.
7
Pulsed Electromagnetic Field Therapy and Direct Current Electric Field Modulation Promote the Migration of Fibroblast-like Synoviocytes to Accelerate Cartilage Repair In Vitro.
Appl Sci (Basel). 2022 Dec 1;12(23). doi: 10.3390/app122312406. Epub 2022 Dec 4.
8
Toward defining the role of the synovium in mitigating normal articular cartilage wear and tear.
J Biomech. 2023 Feb;148:111472. doi: 10.1016/j.jbiomech.2023.111472. Epub 2023 Jan 26.
9
Typical response of CD14CD16 monocyte to knee synovial derived mediators as a key target to overcome the onset and progression of osteoarthritis.
Front Med (Lausanne). 2022 Aug 29;9:904721. doi: 10.3389/fmed.2022.904721. eCollection 2022.
10
Inflammatory cytokines and mechanical injury induce post-traumatic osteoarthritis-like changes in a human cartilage-bone-synovium microphysiological system.
Arthritis Res Ther. 2022 Aug 18;24(1):198. doi: 10.1186/s13075-022-02881-z.
本文引用的文献
1
Intra-articular clearance of labeled dextrans from naive and arthritic rat knee joints.
J Control Release. 2018 Aug 10;283:76-83. doi: 10.1016/j.jconrel.2018.05.029. Epub 2018 May 26.
2
Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activity.
Arthritis Res Ther. 2017 Jul 5;19(1):157. doi: 10.1186/s13075-017-1318-9.
3
Enumeration and Localization of Mesenchymal Progenitor Cells and Macrophages in Synovium from Normal Individuals and Patients with Pre-Osteoarthritis or Clinically Diagnosed Osteoarthritis.
Int J Mol Sci. 2017 Apr 5;18(4):774. doi: 10.3390/ijms18040774.
4
Adipose stromal cells mediated switching of the pro-inflammatory profile of M1-like macrophages is facilitated by PGE2: in vitro evaluation.
Osteoarthritis Cartilage. 2017 Jul;25(7):1161-1171. doi: 10.1016/j.joca.2017.01.011. Epub 2017 Jan 30.
5
Synovitis in osteoarthritis: current understanding with therapeutic implications.
Arthritis Res Ther. 2017 Feb 2;19(1):18. doi: 10.1186/s13075-017-1229-9.
6
Establishment of an in vitro three-dimensional model for cartilage damage in rheumatoid arthritis.
J Tissue Eng Regen Med. 2018 Jan;12(1):e237-e249. doi: 10.1002/term.2399. Epub 2017 May 23.
7
What drives osteoarthritis?-synovial versus subchondral bone pathology.
Rheumatology (Oxford). 2017 Sep 1;56(9):1461-1471. doi: 10.1093/rheumatology/kew389.
8
The joint synovium: A critical determinant of articular cartilage fate in inflammatory joint diseases.
Semin Cell Dev Biol. 2017 Feb;62:86-93. doi: 10.1016/j.semcdb.2016.05.009. Epub 2016 May 19.
9
Guiding synovial inflammation by macrophage phenotype modulation: an in vitro study towards a therapy for osteoarthritis.
Osteoarthritis Cartilage. 2016 Sep;24(9):1629-38. doi: 10.1016/j.joca.2016.04.013. Epub 2016 Apr 14.
10
Characterizing heterogeneity in the response of synovial mesenchymal progenitor cells to synovial macrophages in normal individuals and patients with osteoarthritis.
J Inflamm (Lond). 2016 Apr 6;13:12. doi: 10.1186/s12950-016-0120-9. eCollection 2016.
Zotero 插件