[Network Pharmacological Studies of Puerariae Radix in Improving Insulin Resistance].

OBJECTIVE

To investigate the active components and potential mechanism of Puerariae Radix in improving insulin resistance by using network pharmacological method.

METHODS

Key target proteins related with insulin resistance were selected based on molecular docking technology, and then took the selected components with 31 target proteins of four pathways for docking. Meanwhile, component-target proteins network was established to network analysis by software Cytoscape 3. 2. 1.

RESULTS

19 compounds had close interactions with four pathways such as AMPK. There were 13 compositions can verify through literature, which revealing that active ingredients and potential molecular mechanism of Puerariae Radix in improving insulin resistance, preliminarily.

CONCLUSION

The network pharmacological method is helpful to explore the possible active components in Puerariae Radix and elucidate the mechanism.