Singh Shailendra Pal, Kumar Vishal, Pandey Anand, Pandey Pinki, Gupta Vipin, Verma Rajesh
Department of Surgery, UP University of Medical Sciences, Saifai, Etawah, 206130.
Department of Surgery, UP University of Medical Sciences, Saifai, Etawah, 206130, Department of Pediatric Surgery, King George's Medical University, Lucknow 226003.
J Wound Care. 2018 Sep 2;27(9):550-556. doi: 10.12968/jowc.2018.27.9.550.
To evaluate the role of platelet-rich plasma (PRP) in healing diabetic fool ulcers (DFUs), and to compare the rate of healing and final outcome with conventional therapy.
A prospective study conducted between October 2013 and July 2015. Participants were divided in to two groups: a study group in which PRP was used and a control group receiving standard therapy. Wound assessment was carried out according to the Bates-Jensen Wound Assessment Tool at 0, 7, 14, 21 and 28 days.
A total of 55 patients were recruited to the study. There were 29 patients in the study group and 26 patients in the control group. After application of PRP, there was significant improvement in mean wound score and significant percent improvement in wound score in the study group (p<0.0001). Complete healing occurred in all patients in the study group in (mean score and standard deviation) 36.7±3 days compared with 60.6±3.7 days in the control group (p<0.0001). There were no unwanted side effects in patients using the PRP in this study.
PRP appears to be a promising agent in the management of DFUs. In this study, DFUs healed more quickly in the study group than in the control group. There was also significant percent improvement in wound score as compared with debridement and dressing only. If proper selection criteria are applied, PRP could be a useful aid to wound healing in people with DFUs.
评估富血小板血浆（PRP）在糖尿病足溃疡（DFUs）愈合中的作用，并将其愈合率和最终结果与传统疗法进行比较。
2013年10月至2015年7月进行的一项前瞻性研究。参与者分为两组：使用PRP的研究组和接受标准疗法的对照组。在第0、7、14、21和28天根据贝茨 - 詹森伤口评估工具进行伤口评估。
共有55名患者纳入该研究。研究组有29名患者，对照组有26名患者。应用PRP后，研究组的平均伤口评分有显著改善，伤口评分改善百分比也显著提高（p<0.0001）。研究组所有患者均在（平均评分和标准差）36.7±3天实现完全愈合，而对照组为60.6±3.7天（p<0.0001）。本研究中使用PRP的患者未出现不良副作用。
PRP似乎是治疗DFUs的一种有前景的药物。在本研究中，研究组的DFUs愈合速度比对照组更快。与仅进行清创和换药相比，伤口评分的改善百分比也显著提高。如果应用适当的选择标准，PRP可能有助于DFUs患者的伤口愈合。
