Tajika T, Kubo O, Tajika Y, Toyama T, Himuro H, Inoue N, Sakairi M, Kitamura K
No Shinkei Geka. 1986 Jun;14(7):831-5.
In surgical specimens of 91 cases of malignant glial tumor, the correlation between the clinical malignancy of the tumors and the presence of GFA protein in the surgical specimen was examined. In anaplastic astrocytomas, 20 of 27 cases revealed positive staining of GFAP. In the cases of glioblastoma multiforme 27 of 35 cases showed GFAP positive staining. On the other hand, in medulloblastomas, all 29 cases were negative. In anaplastic astrocytomas and glioblastoma multiforms, the difference between the survival curves of GFAP positive groups and negative groups were examined. Between two groups, there was no statistical differences. In this study, the presence of GFAP was not proportional to the degree of tumor differentiation, and the GFAP staining of the tumor tissue was not a valuable examination showing the prognosis of the patient.
在91例恶性胶质瘤手术标本中，研究了肿瘤临床恶性程度与手术标本中胶质纤维酸性蛋白（GFA蛋白）存在情况之间的相关性。在间变性星形细胞瘤中，27例中有20例显示胶质纤维酸性蛋白（GFAP）染色阳性。在多形性胶质母细胞瘤病例中，35例中有27例显示GFAP染色阳性。另一方面，在髓母细胞瘤中，所有29例均为阴性。在间变性星形细胞瘤和多形性胶质母细胞瘤中，研究了GFAP阳性组和阴性组生存曲线的差异。两组之间无统计学差异。在本研究中，GFAP的存在与肿瘤分化程度不成正比，肿瘤组织的GFAP染色不是显示患者预后的有价值检查。
