白喉酰胺介导的蛋白质翻译控制的隐秘本质：皮革之下的秘密。
The hidden nature of protein translational control by diphthamide: the secrets under the leather.
作者信息
Tsuda-Sakurai Kayoko, Miura Masayuki
机构信息
Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
出版信息
J Biochem. 2019 Jan 1;165(1):1-8. doi: 10.1093/jb/mvy071.
The protein translation elongation factor eEF2 undergoes a unique posttranslational modification called diphthamidation. eEF2 is an essential factor in protein translation, and the diphthamide modification has been a famous target of the diphtheria toxin for a long time. On the other hand, the physiological function of this rare modification in vivo remains unknown. Recent studies have suggested that diphthamide has specific functions for the cellular stress response and active proliferation. In this review, we summarize the history and findings of diphthamide obtained to date and discuss the possibility of a specific function for diphthamide in regulating protein translation.
蛋白质翻译延伸因子eEF2会经历一种名为二磷酸腺苷核糖基化修饰的独特翻译后修饰。eEF2是蛋白质翻译中的一个关键因子，长期以来，二磷酸腺苷核糖基化修饰一直是白喉毒素的著名作用靶点。另一方面，这种罕见修饰在体内的生理功能仍然未知。最近的研究表明，二磷酸腺苷核糖基化修饰在细胞应激反应和活跃增殖方面具有特定功能。在这篇综述中，我们总结了迄今为止关于二磷酸腺苷核糖基化修饰的研究历史和发现，并探讨了二磷酸腺苷核糖基化修饰在调节蛋白质翻译中具有特定功能的可能性。
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