Department of Cell Biology, Harvard Medical School, Boston, MA, USA; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
Department of Cell Biology, Harvard Medical School, Boston, MA, USA; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
Trends Cell Biol. 2022 Sep;32(9):762-772. doi: 10.1016/j.tcb.2022.03.006. Epub 2022 Apr 21.
Translation factors have traditionally been viewed as proteins that drive ribosome function and ensure accurate mRNA translation. Recent discoveries have highlighted that these factors can also moonlight in gene regulation, but through functions distinct from their canonical roles in protein synthesis. Notably, the additional functions that translation factors encode are diverse, ranging from transcriptional control and extracellular signaling to RNA binding, and are highly regulated in response to external cues and the intrinsic cellular state. Thus, this multifunctionality of translation factors provides an additional mechanism for exquisite control of gene expression.
传统上,翻译因子被视为驱动核糖体功能并确保 mRNA 翻译准确性的蛋白质。最近的发现强调了这些因子还可以在基因调控中兼职,但通过与其在蛋白质合成中的典型作用不同的功能。值得注意的是,翻译因子编码的额外功能多种多样,从转录控制和细胞外信号传导到 RNA 结合,并且对外界线索和内在细胞状态的响应高度受到调节。因此,翻译因子的这种多功能性为精细控制基因表达提供了另一种机制。