大鼠下丘脑中不同形式促肾上腺皮质激素的存在。
Existence of different forms of adrenocorticotropin in rat hypothalamus.
作者信息
Argiolas A, Melis M R, Fratta W, Gessa G L
出版信息
Peptides. 1986 Jul-Aug;7(4):591-6. doi: 10.1016/0196-9781(86)90032-x.
Adrenocorticotropin (ACTH)-like immunoreactivity and bioactivity were extracted from rat hypothalamus and fractionated by high pressure liquid chromatography. Analysis of the fractions either by radioimmunoassay or bioassay (corticosteroid production from rat adrenal cells) revealed several peaks of immunoreactivity and bioactivity. Only 20-25% of total ACTH-like immunoreactivity and bioactivity eluted with the same retention time as authentic ACTH 1-39. The results suggest that different forms of ACTH exist in rat hypothalamus.
促肾上腺皮质激素（ACTH）样免疫反应性和生物活性从大鼠下丘脑提取，并用高压液相色谱法进行分离。通过放射免疫测定法或生物测定法（大鼠肾上腺细胞产生皮质类固醇）对这些馏分进行分析，发现了几个免疫反应性和生物活性峰。只有20%-25%的总ACTH样免疫反应性和生物活性与天然ACTH 1-39以相同的保留时间洗脱。结果表明，大鼠下丘脑存在不同形式的ACTH。
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