Clinical Pharmacology Service, Hospital Universitari Vall d'Hebron. Barcelona, Spain.
MSc Pharmacology, Universitat Autònoma de Barcelona, Barcelona, Spain.
Psychiatry Res. 2018 Nov;269:593-595. doi: 10.1016/j.psychres.2018.09.008. Epub 2018 Sep 5.
The widespread use of dopaminergic agents for the treatment of Parkinson's disease has revealed the presence of gambling disorder (GD) as an uncommon, but serious, adverse reaction to these agents. We describe the main characteristics of drug-induced GD reports received by the Spanish Pharmacovigilance System during the period from 1983 to 2016. Fifteen reports of GD have been identified. Dopaminergic agonists, especially pramipexole, are the main drugs involved in inducing GD. Physicians prescribing these drugs should warn patients and families about this disorder. Knowledge of this disorder will encourage early diagnosis, treatment, and reporting of this clinically and socially relevant disorder.
多巴胺能药物在帕金森病治疗中的广泛应用，揭示了赌博障碍（GD）是这些药物一种不常见但严重的不良反应。我们描述了西班牙药物警戒系统在 1983 年至 2016 年期间收到的药物引起的 GD 报告的主要特征。已确定 15 例 GD 报告。多巴胺能激动剂，特别是普拉克索，是引起 GD 的主要药物。开具这些药物的医生应警告患者及其家属存在这种障碍。了解这种疾病将鼓励对这种具有临床和社会意义的疾病进行早期诊断、治疗和报告。
