Schechter M D
Pharmacol Biochem Behav. 1986 Aug;25(2):337-40. doi: 10.1016/0091-3057(86)90006-7.
Ten male rats were trained to discriminate between the stimulus properties of 0.6 mg/kg l-cathinone and saline in a two-lever food-motivated operant task. Once trained, rats showed a dose-dependent increase in discrimination over a dosage range of 0.15-1.2 mg/kg l-cathinone. Analysis of this dose-response relationship indicated an ED50 of 0.27 mg/kg. Pretreatment with 0.2 mg/kg of the specific dopamine blocking drug haloperidol increased this ED50 to 0.47 mg/kg and significantly decreased discriminative performance when co-administered with either 0.15, 0.3, or 0.6 mg/kg l-cathinone. Since the dose-effect curves for cathinone with and without haloperidol pre-treatment were parallel, it is suggested that l-cathinone, the active constituent in khat, produces its discriminative properties, in part, by mediation of dopaminergic neuronal systems.
十只雄性大鼠在一项双杠杆食物驱动的操作性任务中接受训练，以区分0.6毫克/千克左旋卡西酮和生理盐水的刺激特性。一旦训练完成，大鼠在0.15 - 1.2毫克/千克左旋卡西酮的剂量范围内，辨别能力呈剂量依赖性增加。对这种剂量反应关系的分析表明，半数有效剂量（ED50）为0.27毫克/千克。用0.2毫克/千克的特定多巴胺阻断药物氟哌啶醇预处理后，该ED50增加到0.47毫克/千克，并且当与0.15、0.3或0.6毫克/千克左旋卡西酮共同给药时，显著降低辨别性能。由于有和没有氟哌啶醇预处理的卡西酮剂量效应曲线是平行的，表明阿拉伯茶中的活性成分左旋卡西酮部分通过多巴胺能神经元系统的介导产生其辨别特性。
