Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.
Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA.
J Perinatol. 2018 Nov;38(11):1466-1470. doi: 10.1038/s41372-018-0225-5. Epub 2018 Sep 11.
Antenatal steroids (ANS) are used widely for women at risk of preterm delivery. Evidence on the effects of ANS on thyroid hormone function in preterm infants is limited.
To determine effects of ANS on thyroid hormone function in preterm infants.
A retrospective cohort study of preterm infants born before 30 weeks of gestation. Infants were divided into no ANS, partial ANS, and complete ANS groups. Thyroid function tests at day of life 30 were compared.
260 Infants were included. A significantly higher proportion of patients were started on levothyroxine (LT4) in no ANS group and partial ANS group compared to complete ANS group. Logistic regression analysis revealed that infants in no ANS group are more likely to have TSH > 6 μIU ml and started on LT4 compared to complete ANS group.
Infants in no ANS group are more likely to have thyroid dysfunction compared to complete ANS group.
产前类固醇（ANS）广泛用于有早产风险的妇女。关于 ANS 对早产儿甲状腺激素功能影响的证据有限。
确定 ANS 对早产儿甲状腺激素功能的影响。
对胎龄小于 30 周的早产儿进行回顾性队列研究。将婴儿分为无 ANS、部分 ANS 和完全 ANS 组。比较生后 30 天的甲状腺功能检查结果。
共纳入 260 例婴儿。与完全 ANS 组相比，无 ANS 组和部分 ANS 组中开始服用左甲状腺素（LT4）的患者比例明显更高。Logistic 回归分析显示，与完全 ANS 组相比，无 ANS 组的婴儿 TSH>6μIU/ml 和开始服用 LT4 的可能性更高。
与完全 ANS 组相比，无 ANS 组的婴儿更有可能出现甲状腺功能障碍。
