Mrozek-Budzyn Dorota, Majewska Renata, Kieltyka Agnieszka, Augustyniak Malgorzata
Department of Epidemiology, Chair of Epidemiology and Preventive Medicine, Jagiellonian University Medical College, Krakow, Poland.
Postepy Dermatol Alergol. 2018 Aug;35(4):381-386. doi: 10.5114/ada.2018.77668. Epub 2018 Aug 21.
Vaccine opponents indicate that the infant's immune system is inadequately developed to handle multiple vaccines which may overwhelm the immune system, leading to allergic diseases.
To verify the association between the vaccine antigen overload derived from DTwP and the development of atopic sensitization and allergic diseases.
Data from an earlier established birth cohort in Krakow, followed up to the 6 year of life were used. Allergic diseases such as eczema, hay fever and asthma were diagnosed by a physician and reported every half a year from the 1 to 6 year of life by the child's parent. Skin prick tests (SPT) were performed in children at 5 years of age. The data on infants' vaccination were extracted from the physician's records. The status of vaccine antigen exposure was based on different types of vaccines against pertussis (DTwP or DTaP) in a primary course. Results were determined by multiple logistic regression, adjusted to potential confounders.
The analyzed population consisted of 234 children: 53.4% - boys and 46.6% - girls. Infants up to the age of 8 months were vaccinated with the primary course against pertussis, with DTwP - 60.7%, DTaP - 32.9% and further 6.4% with a mixed course (DTwP + DTaP). There were no significant relationships between any of vaccination groups and allergic disease and allergen sensitivity in the multiple logistic regression model with adjustment to potential confounders.
The exposure to a large number of vaccine antigens derived from DTwP has no influence on the development of allergic diseases and atopic sensitization in children.
疫苗反对者指出，婴儿的免疫系统发育不完善，无法应对多种疫苗，这可能会使免疫系统不堪重负，从而引发过敏性疾病。
验证由百白破疫苗（DTwP）引起的疫苗抗原过载与特应性致敏及过敏性疾病发展之间的关联。
使用来自克拉科夫一个早期建立的出生队列的数据，随访至儿童6岁。湿疹、花粉热和哮喘等过敏性疾病由医生诊断，并由儿童家长在儿童1至6岁期间每半年报告一次。在儿童5岁时进行皮肤点刺试验（SPT）。婴儿疫苗接种数据从医生记录中提取。疫苗抗原暴露状况基于初次接种过程中针对百日咳的不同类型疫苗（DTwP或DTaP）。结果通过多元逻辑回归确定，并对潜在混杂因素进行了调整。
分析的人群包括234名儿童：53.4%为男孩，46.6%为女孩。8个月以下婴儿接种了针对百日咳的初次疫苗，其中接种DTwP的占60.7%，接种DTaP的占32.9%，另有6.4%接种了混合疫苗（DTwP + DTaP）。在对潜在混杂因素进行调整的多元逻辑回归模型中，任何疫苗接种组与过敏性疾病及过敏原敏感性之间均无显著关系。
接触来自DTwP的大量疫苗抗原对儿童过敏性疾病和特应性致敏的发展没有影响。
